{"type":"trials","record":{"id":36613,"source_id":"clinicaltrials-gov","external_id":"NCT02628548","title":"Neural Correlates of Successful Cognitive Aging","brief_summary":"Normal aging is associated with gradual cognitive declines. These mild neurocognitive disturbances affect daily functioning, health status, and quality of life, and likely account for the roughly $2.9 billion lost by the elderly each year to fraud. The goal of this project is to compare two different 8-week training programs to promote successful neural and cognitive aging. Changes in neural structure and cognitive function will be assessed in a cohort of older adults, as well as the long-term stability of these changes over 24 months.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Massachusetts General Hospital","enrollment":175,"countries":["United States"],"start_date":"2016-01-18","completion_date":"2021-12-31","last_update_date":"2022-09-07","source_url":"https://clinicaltrials.gov/study/NCT02628548","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:26.090953+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 85 Years","comparator":null,"organization":"Massachusetts General Hospital","interventions":["Cognitive training program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in brain structure — 8 weeks","Change in brain activity during a memory test — 8 weeks","Blood markers — baseline, 8 weeks, 12 and 24 months","Change in cognition — 2 years"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · TRIPLE","source_has_results":false},"controlled_terms":["Aging","Cognitive training program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct02628548","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-01-18 to 2021-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.910Z","intervention":["Cognitive training program"],"participants":175,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in brain structure — 8 weeks","Change in brain activity during a memory test — 8 weeks","Blood markers — baseline, 8 weeks, 12 and 24 months","Change in cognition — 2 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive aging.","Abstract contains controlled term: cognitive aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36613","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}