{"type":"trials","record":{"id":36616,"source_id":"clinicaltrials-gov","external_id":"NCT03039647","title":"Insulin Resistance and Accelerated Cognitive Aging","brief_summary":"Premature and accelerated brain aging trajectories have been observed among people with metabolic dysfunction, but mechanisms of these altered trajectories are not understood. Insulin resistance (IR) is known to change with age and affect cognition in older and elderly adults as well as in patients with mood disorders. The main purpose of the study is to describe the developmental trajectory of cognitive and neural biomarkers across the spectrum of metabolic dysfunction in overweight/obese adults younger than 50 years of age. The innovative study design will allow the investigators to examine cognitive outcome development over a 25-year span without an investment into the longitudinal observation of changes in cognition and neural function.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Stanford University","enrollment":126,"countries":["United States"],"start_date":"2017-01-01","completion_date":"2022-05-01","last_update_date":"2022-05-09","source_url":"https://clinicaltrials.gov/study/NCT03039647","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:26.090953+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"25 Years to 50 Years","comparator":null,"organization":"Stanford University","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in hippocampal connectivity — Change in hippocampal connectivity from entry point to exit point three years later","Change in hippocampal volume — Change in hippocampal volume from entry point to exit point three years later","Change in memory-related functional activation — Change in memory-related functional activation from entry point to exi…"],"design_description":null,"source_has_results":false},"controlled_terms":["Insulin Resistance"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct03039647","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-01-01 to 2022-05-01","comparator":null,"confidence":"structured-source","population":"ALL · 25 Years to 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.911Z","intervention":[],"participants":126,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in hippocampal connectivity — Change in hippocampal connectivity from entry point to exit point three years later","Change in hippocampal volume — Change in hippocampal volume from entry point to exit point three years later","Change in memory-related functional activation — Change in memory-related functional activation from entry point to exi…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive aging.","Abstract contains controlled term: brain aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36616","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}