{"type":"trials","record":{"id":36619,"source_id":"clinicaltrials-gov","external_id":"NCT03677726","title":"Improving Sleep Continuity Through Mindfulness Training for Better Cognitive Ageing.","brief_summary":"Poor sleep quality is a known risk factor for cognitive decline in the elderly. Hearteningly, sleep is also a prime target for behavioral modification. In this study, the investigators propose to test mindfulness-based training (MBT) as an intervention to improve sleep quality by reducing sleep fragmentation, and hypothesize that these improvements will mediate the beneficial effects of MBT on sustained and executive attention. MBT consists of a suite of techniques aimed at enhancing awareness and acceptance of one's internal (e.g., thoughts and feelings) and external experiences in the present moment. Learning these techniques has been shown to improve sleep quality in patients with primary insomnia, and in other conditions associated with sleep disturbance. There is also increasing evidence that mindfulness training enhances multiple facets of cognition, including components of attention. In this study, the investigators will recruit 120 participants in a randomized controlled design, with 60 participants receiving MBT, and 60 receiving a sleep hygiene education and exercise program (SHEEP). Each intervention will last 8 weeks. Before and after the intervention, the investigators will collect objective and subjective measures of sleep quality, resting-state and task-related functional magnetic resonance imaging scans, and performance on standard laboratory tests of attention. The investigators hypothesize that, relative to SHE, MBT will result in significantly greater improvements in sleep quality and attentional metrics. They also predict that the cognitive changes will be mediated by the changes in sleep quality. If a positive result is found, this would indicate the use of MBT as a cost-effective behavioral intervention to stabilize or even improve cognition in the elderly, thus reducing the risk of dementia in this vulnerable population.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Singapore General Hospital","enrollment":150,"countries":["Singapore"],"start_date":"2018-08-01","completion_date":"2021-06-10","last_update_date":"2021-06-15","source_url":"https://clinicaltrials.gov/study/NCT03677726","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:26.090953+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":"MIST","age_range":"50 Years to 80 Years","comparator":"Sleep Hygiene Education Exercise Program","organization":"Singapore General Hospital","interventions":["Mindfulness Based Therapy for Insomnia","Sleep Hygiene Education Exercise Program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Subjective measures of Sleep quality: Pittsburgh Sleep Quality Index Score — Up to one month","Polysomnography: objective changes in sleep onset latency (SOL) — One night","Actiwatch: objective changes in sleep onset latency (SOL) — One week","Polysomnography: objective changes in wake after sleep onset (WASO) — One night","Actiwatch: objective changes in wake after sleep onset (WASO) — One week","Change in Subjective measures of Sleep quality: Insomnia Severity Index — Past two weeks","Change in Cognitive and Attention tasks performance (CANTAB: Reaction time task) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Rapid Visual Information Processing primary outcome) — Up…","Change in Cognitive and Attention tasks performance (CANTAB: Paired Associate Learning) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Spatial Working Memory) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Stocking of Cambridge) — Up to 10 minutes","Imaging measures (structural): change in orbitofrontal cortex volume — 6 minutes","Change in functional imaging measures: Resting state and Inscape — 10 minutes","Change in functional imaging measures: Breath counting task — 10 minutes","Change in functional imaging measures: Letting go practice — 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Emotion Recognition Task) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Verbal Recognition Memory) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Rapid Visual Information Processing) — Up to 10 minutes","Behavioral Breath counting task: Errors — 20 minutes","Behavioral Breath counting task: Accuracy — 20 minutes"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Sleep Initiation and Maintenance Disorders","Cognitive Aging","Mindfulness Based Therapy for Insomnia","Sleep Hygiene Education Exercise Program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive ageing.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct03677726","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-08-01 to 2021-06-10","comparator":"Sleep Hygiene Education Exercise Program","confidence":"structured-source","population":"ALL · 50 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.911Z","intervention":["Mindfulness Based Therapy for Insomnia","Sleep Hygiene Education Exercise Program"],"participants":150,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Subjective measures of Sleep quality: Pittsburgh Sleep Quality Index Score — Up to one month","Polysomnography: objective changes in sleep onset latency (SOL) — One night","Actiwatch: objective changes in sleep onset latency (SOL) — One week","Polysomnography: objective changes in wake after sleep onset (WASO) — One night","Actiwatch: objective changes in wake after sleep onset (WASO) — One week","Change in Subjective measures of Sleep quality: Insomnia Severity Index — Past two weeks","Change in Cognitive and Attention tasks performance (CANTAB: Reaction time task) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Rapid Visual Information Processing primary outcome) — Up…","Change in Cognitive and Attention tasks performance (CANTAB: Paired Associate Learning) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Spatial Working Memory) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Stocking of Cambridge) — Up to 10 minutes","Imaging measures (structural): change in orbitofrontal cortex volume — 6 minutes","Change in functional imaging measures: Resting state and Inscape — 10 minutes","Change in functional imaging measures: Breath counting task — 10 minutes","Change in functional imaging measures: Letting go practice — 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Emotion Recognition Task) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Verbal Recognition Memory) — Up to 10 minutes","Change in Cognitive and Attention tasks performance (CANTAB: Rapid Visual Information Processing) — Up to 10 minutes","Behavioral Breath counting task: Errors — 20 minutes","Behavioral Breath counting task: Accuracy — 20 minutes"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive ageing.","Source terminology contains: cognitive aging.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}},{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Source terminology contains: sleep.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36619","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}