{"type":"trials","record":{"id":36644,"source_id":"clinicaltrials-gov","external_id":"NCT02391311","title":"A Novel Neurorehabilitation Approach for Cognitive Aging With HIV","brief_summary":"The goal of this study is to conduct a small, self-contained project to test the hypothesis that tDCS will augment SOP cognitive remediation therapy (CRT) in older HIV+ adults. The investigators will randomly assign 60 HIV+ older adults (i.e., ≥ 50 years old) to 10-hours in either a SOP CRT + sham tDCS condition (n=30) or SOP CRT + active tDCS condition (n=30) and examine neurocognitive functioning at baseline and 6 weeks post-intervention. Hypothesis 1: The SOP CRT + active tDCS condition will show larger proximal (i.e., SOP) gains than the SOP CRT + sham tDCS condition. Hypothesis 2: The active tDCS condition will demonstrate generalization to secondary neurocognitive domains compared to the sham tDCS condition.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Alabama at Birmingham","enrollment":42,"countries":["United States"],"start_date":"2015-03-01","completion_date":"2016-01-01","last_update_date":"2017-05-15","source_url":"https://clinicaltrials.gov/study/NCT02391311","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:26.090953+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":"HtDCS","age_range":"50 Years","comparator":"Sham tDCS + Cognitive Remediation","organization":"University of Alabama at Birmingham","interventions":["transcranial direct current stimulation (tDCS)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in the Processing of Speed — baseline, 6 week posttest","Change in Driving Simulator Performance — baseline, 6 week posttest"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":true},"controlled_terms":["HIV","Aging","transcranial direct current stimulation (tDCS)"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct02391311","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-03-01 to 2016-01-01","comparator":"Sham tDCS + Cognitive Remediation","confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.916Z","intervention":["transcranial direct current stimulation (tDCS)"],"participants":42,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in the Processing of Speed — baseline, 6 week posttest","Change in Driving Simulator Performance — baseline, 6 week posttest"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36644","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}