{"type":"trials","record":{"id":36809,"source_id":"clinicaltrials-gov","external_id":"NCT05872139","title":"Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging","brief_summary":"The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Ball State University","enrollment":23,"countries":["United States"],"start_date":"2022-09-23","completion_date":"2023-05-01","last_update_date":"2023-05-24","source_url":"https://clinicaltrials.gov/study/NCT05872139","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:27.21097+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":"Placebo","organization":"Ball State University","interventions":["Placebo","Mitoquinone Mesylate"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in vascular endothelial function — Baseline and Post 1 hour","Change in cardiovascular function — Baseline and Post 1 hour","Change in Aortic Stiffness — Baseline and Post 1 hour","Change in carotid artery stiffness - beta-stiffness index — Baseline and Post 1 hour","Change in carotid artery compliance — Baseline and Post 1 hour","Change in carotid artery distensibility — Baseline and Post 1 hour","Change in carotid artery Young's elastic modulus — Baseline and Post 1 hour"],"design_description":"RANDOMIZED · CROSSOVER · OTHER · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Endothelial Dysfunction","Cardiovascular Function","Arterial Stiffness","Placebo","Mitoquinone Mesylate"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: oxidative stress.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct05872139","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-09-23 to 2023-05-01","comparator":"Placebo","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.327Z","intervention":["Placebo","Mitoquinone Mesylate"],"participants":23,"study_design":"RANDOMIZED · CROSSOVER · OTHER · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in vascular endothelial function — Baseline and Post 1 hour","Change in cardiovascular function — Baseline and Post 1 hour","Change in Aortic Stiffness — Baseline and Post 1 hour","Change in carotid artery stiffness - beta-stiffness index — Baseline and Post 1 hour","Change in carotid artery compliance — Baseline and Post 1 hour","Change in carotid artery distensibility — Baseline and Post 1 hour","Change in carotid artery Young's elastic modulus — Baseline and Post 1 hour"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36809","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}