{"type":"trials","record":{"id":36823,"source_id":"clinicaltrials-gov","external_id":"NCT05645991","title":"Coconut Sugar Lowers Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults","brief_summary":"The goal of this intervention is to determine the efficacy of coconut sap powder (CSP) to lower arterial stiffness and blood pressure in middle-aged and older adults. Participants will be randomized to the CSP arm or Placebo arm of the study. Primary endpoints include: aortic stiffness assessed by carotid-femoral pulse wave velocity, resting brachial and (non-invasive) carotid blood pressure, and carotid stiffness (e.g. Beta stiffness index, Carotid compliance, Elastic modulus, Distensibility).","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Ball State University","enrollment":22,"countries":["United States"],"start_date":"2018-03-08","completion_date":"2022-01-20","last_update_date":"2022-12-12","source_url":"https://clinicaltrials.gov/study/NCT05645991","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:27.21097+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"40 Years to 80 Years","comparator":"Placebo","organization":"Ball State University","interventions":["Coconut Sap Powder (CSP)","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in aortic stiffness — Baseline and 8 weeks","Change in systolic and diastolic brachial blood pressure — Baseline and 8 weeks","Change in carotid systolic and diastolic blood pressure — Baseline and 8 weeks","Change in carotid artery stiffness - beta stiffness index — Baseline and 8 weeks","Change in carotid artery stiffness - carotid compliance — Baseline and 8 weeks","Change in carotid artery stiffness - elastic modulus — Baseline and 8 weeks","Change in carotid artery stiffness - Young's modulus — Baseline and 8 weeks","Change in carotid artery stiffness - distensibility — Baseline and 8 weeks","Change in inflammatory biomarker - interleukin 6 — Baseline and 8 weeks","Change in inflammatory biomarker - interleukin 10 — Baseline and 8 weeks","Change in inflammatory biomarker - interleukin 1 beta — Baseline and 8 weeks","Change in inflammatory biomarker - tumor necrosis factor alpha — Baseline and 8 weeks","Change in inflammatory biomarker - monocyte chemoattractant protein 1 — Baseline and 8 weeks","Change in inflammatory biomarker - high sensitivity C-reactive protein — Baseline and 8 weeks","Change in oxidative stress biomarkers - superoxide dismutase — Baseline and 8 weeks","Change in oxidative stress biomarkers - Catalase — Baseline and 8 weeks","Change in oxidative stress biomarkers - Oxidized low density lipoprotein — Baseline and 8 weeks"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Blood Pressure","Arterial Stiffness","Coconut Sap Powder (CSP)","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: arterial stiffness.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct05645991","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-03-08 to 2022-01-20","comparator":"Placebo","confidence":"structured-source","population":"ALL · 40 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.464Z","intervention":["Coconut Sap Powder (CSP)","Placebo"],"participants":22,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in aortic stiffness — Baseline and 8 weeks","Change in systolic and diastolic brachial blood pressure — Baseline and 8 weeks","Change in carotid systolic and diastolic blood pressure — Baseline and 8 weeks","Change in carotid artery stiffness - beta stiffness index — Baseline and 8 weeks","Change in carotid artery stiffness - carotid compliance — Baseline and 8 weeks","Change in carotid artery stiffness - elastic modulus — Baseline and 8 weeks","Change in carotid artery stiffness - Young's modulus — Baseline and 8 weeks","Change in carotid artery stiffness - distensibility — Baseline and 8 weeks","Change in inflammatory biomarker - interleukin 6 — Baseline and 8 weeks","Change in inflammatory biomarker - interleukin 10 — Baseline and 8 weeks","Change in inflammatory biomarker - interleukin 1 beta — Baseline and 8 weeks","Change in inflammatory biomarker - tumor necrosis factor alpha — Baseline and 8 weeks","Change in inflammatory biomarker - monocyte chemoattractant protein 1 — Baseline and 8 weeks","Change in inflammatory biomarker - high sensitivity C-reactive protein — Baseline and 8 weeks","Change in oxidative stress biomarkers - superoxide dismutase — Baseline and 8 weeks","Change in oxidative stress biomarkers - Catalase — Baseline and 8 weeks","Change in oxidative stress biomarkers - Oxidized low density lipoprotein — Baseline and 8 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: arterial stiffness.","Abstract contains controlled term: arterial stiffness.","Source terminology contains: arterial stiffness.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36823","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}