{"type":"trials","record":{"id":36832,"source_id":"clinicaltrials-gov","external_id":"NCT03649802","title":"Vitamin D and Arterial Stiffness in Elderly","brief_summary":"Investigators will examine arterial stiffness and pulse waveform analysis. Subjects with vitamin D insufficiency will be recruited. A double blind randomized controlled study will examine the effects of standard dose vitamin D3 (800 IU) versus higher dose vitamin D3 (5000 IU)-given on a daily basis.In order to understand mechanisms of action by which vitamin D would improve arterial stiffness investigators will use biomarkers. Oxidative and inflammatory stress will be measured by plasma F2-isoprostanes and Sulforaphane levels.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Texas Tech University Health Sciences Center","enrollment":52,"countries":["United States"],"start_date":"2018-08-16","completion_date":"2021-12-31","last_update_date":"2022-03-21","source_url":"https://clinicaltrials.gov/study/NCT03649802","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:27.21097+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 89 Years","comparator":"Low dose Vitamin D-800 IU; High dose Vitamin D-5000 IU","organization":"Texas Tech University Health Sciences Center","interventions":["Low dose vitamin D3","High dose vitamin D3"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Carotid-femoral pulse wave velocity measured by equipment provided by Complior pulse wave analysis — 1 year","24 hour BP ambulatory monitoring — 1 year","Heart rate variability — 1 year","Plasma sulphoraphane and F2-isoprostanes. Isoprostanes will be measured by gas chromatography mass spectrometry and sul…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Vitamin D Deficiency","Arterial Stiffness","Low dose vitamin D3","High dose vitamin D3"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: arterial stiffness.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct03649802","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-08-16 to 2021-12-31","comparator":"Low dose Vitamin D-800 IU; High dose Vitamin D-5000 IU","confidence":"structured-source","population":"ALL · 65 Years to 89 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.468Z","intervention":["Low dose vitamin D3","High dose vitamin D3"],"participants":52,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Carotid-femoral pulse wave velocity measured by equipment provided by Complior pulse wave analysis — 1 year","24 hour BP ambulatory monitoring — 1 year","Heart rate variability — 1 year","Plasma sulphoraphane and F2-isoprostanes. Isoprostanes will be measured by gas chromatography mass spectrometry and sul…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: arterial stiffness.","Abstract contains controlled term: arterial stiffness.","Source terminology contains: arterial stiffness.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36832","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}