{"type":"trials","record":{"id":36833,"source_id":"clinicaltrials-gov","external_id":"NCT03272737","title":"Low Intensity Training Combined With KAATSU on Muscle Vasodilatation and Arterial Stiffness in the Elderly Population","brief_summary":"The purpose of the present study is to evaluate the acute and chronic effect of low intensity strength training with or without moderate blood flow restriction on muscle vasodilation and arterial stiffness in elders with low gait speed. In addition, the responses of prothrombotic factors in blood coagulation, the impact on heart rate and arterial pressure will be assessed.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Hospital Israelita Albert Einstein","enrollment":26,"countries":["Brazil"],"start_date":"2018-02-04","completion_date":"2022-01-04","last_update_date":"2022-02-11","source_url":"https://clinicaltrials.gov/study/NCT03272737","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:27.21097+00:00","last_seen_at":"2026-09-25T06:10:49.917+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years to 85 Years","comparator":"Traditional strength exercise; Strength exercise with KAATSU","organization":"Hospital Israelita Albert Einstein","interventions":["1RM Test","Speed gait test","Venous occlusion plethysmography protocol","Measurement of Arterial Stiffness - Pulse Wave Analysis and Velocity","Isometric handgrip exercise protocol","Vasodilatory capacity","Basal blood flow and vasodilatory capacity - Flow mediated dilation (FMD)","Quality of Life EuroQol-5 Domain","Anthropometric Assessment"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Anthropometric Assessment — Before and after 12 weeksof training","Coagulation factors — Before and after 12 weeksof training","Tolerability, adherence and adverse effects — Before and after 12 weeks of training","Arterial pressure and heart rate — Before and after 12 weeks of training","Speed Gait — Before and after 12 weeks of training"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Frail Elderly Syndrome","1RM Test","Speed gait test","Venous occlusion plethysmography protocol","Measurement of Arterial Stiffness - Pulse Wave Analysis and Velocity","Isometric handgrip exercise protocol","Vasodilatory capacity","Basal blood flow and vasodilatory capacity - Flow mediated dilation (FMD)","Quality of Life EuroQol-5 Domain","Anthropometric Assessment"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: arterial stiffness.","quality_checked_at":"2026-09-25T06:10:57.79658+00:00","duplicate_cluster_key":"id:nct03272737","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-02-04 to 2022-01-04","comparator":"Traditional strength exercise; Strength exercise with KAATSU","confidence":"structured-source","population":"ALL · 60 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:49.948Z","intervention":["1RM Test","Speed gait test","Venous occlusion plethysmography protocol","Measurement of Arterial Stiffness - Pulse Wave Analysis and Velocity","Isometric handgrip exercise protocol","Vasodilatory capacity","Basal blood flow and vasodilatory capacity - Flow mediated dilation (FMD)","Quality of Life EuroQol-5 Domain","Anthropometric Assessment"],"participants":26,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Anthropometric Assessment — Before and after 12 weeksof training","Coagulation factors — Before and after 12 weeksof training","Tolerability, adherence and adverse effects — Before and after 12 weeks of training","Arterial pressure and heart rate — Before and after 12 weeks of training","Speed Gait — Before and after 12 weeks of training"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: arterial stiffness.","Abstract contains controlled term: arterial stiffness.","Source terminology contains: arterial stiffness.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36833","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}