{"type":"trials","record":{"id":36850,"source_id":"clinicaltrials-gov","external_id":"NCT04651894","title":"Relationship Between Digital Vascular Function Measured by EndoPAT® in elderlY Patients and Arterial Stiffness","brief_summary":"Due to the aging of populations worldwide, we observe an increase of age-related diseases and loss of autonomy with consequent personal, social, medical and economic implications. The aging population is a target for geriatric medicine, necessitating the development of specific diagnostic and therapeutic approaches in order to estimate cardio vascular risk in these individuals. It is thought that arterial stiffening and endothelial dysfunction are among the earliest vascular properties altered with the onset of cardiovascular disease. Moreover aging is characterized by progressive fragmentation and break down of the elastic components of the aortic media, which are partially replaced by highly cross-linked collagen leading to stiffening, dilation, and elongation of the aorta . A major underlying mechanism of these modifications is endothelial dysfunction due to high oxidative stress and low-grade inflammation. Reactive hyperemia index (RHI), a key outcome of peripheral arterial tonometry (PAT) has recently become a reliable tool to measure microvascular endothelial function. Some studies have recently demonstrated the interest to measure in elderly patients arterial stiffness parameters in order to prevent loss of autonomy. This cross sectional study aimed at demonstrating the link between arterial stiffness evaluated by pulse wave velocity and endothelial dysfunction evaluated by RHI to implement the tools of cardio vascular risk evaluation in a population of elderly patients referred in a geriatric day hospital.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Central Hospital, Nancy, France","enrollment":148,"countries":["France"],"start_date":"2018-05-01","completion_date":"2020-11-03","last_update_date":"2020-12-04","source_url":"https://clinicaltrials.gov/study/NCT04651894","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:27.21097+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":"ENDY","age_range":"60 Years","comparator":null,"organization":"Central Hospital, Nancy, France","interventions":["reactive hyperaemia index measurement"],"registry_source":"ClinicalTrials.gov","outcome_measures":["endothelial dysfunction — 20 minutes","pulse wave velocity — 10 minutes","PAT signal QUALITY — 10 minutes"],"design_description":null,"source_has_results":false},"controlled_terms":["Arterial Disease","Frail Elderly Syndrome","Stiffness, Vascular","Endothelial Degeneration","reactive hyperaemia index measurement"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: arterial stiffness.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct04651894","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-05-01 to 2020-11-03","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.475Z","intervention":["reactive hyperaemia index measurement"],"participants":148,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["endothelial dysfunction — 20 minutes","pulse wave velocity — 10 minutes","PAT signal QUALITY — 10 minutes"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: arterial stiffness.","Abstract contains controlled term: arterial stiffness.","Title supplies longevity context: elderly.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36850","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}