{"type":"trials","record":{"id":36895,"source_id":"clinicaltrials-gov","external_id":"NCT01692301","title":"Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension","brief_summary":"The study examined the efficacy of LCZ696 in comparison to the ARB olmesartan on Central Aortic Systolic Blood Pressure (CASP) and other measures of central hemodynamics and arterial stiffness in elderly patients with an elevated systolic blood pressure (SBP) and widened pulse pressure (PP).","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Novartis Pharmaceuticals","enrollment":454,"countries":["United States","Argentina","Colombia","France","Germany","Greece","Italy","Japan","Russia","South Korea","Spain","Taiwan"],"start_date":"2012-12-01","completion_date":"2015-04-01","last_update_date":"2016-05-04","source_url":"https://clinicaltrials.gov/study/NCT01692301","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:27.21097+00:00","last_seen_at":"2026-09-25T06:10:49.917+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Olmesartan","organization":"Novartis","interventions":["LCZ696","Olmesartan","LCZ696 matching placebo","Olmesartan matching placebo","amlodipine","hydrochlorothiazide"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change From Baseline in Mean Central Aortic Systolic Pressure (CASP) at 12 Weeks — baseline, 12 weeks","Change From Baseline in Mean Central Pulse (CPP) Pressure — Baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Pulse Wave Velocity (PWV) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Central Aortic Systolic Pressure (CASP) at 52 Weeks — baseline, 52 weeks","Change From Baseline in Mean Sitting Systolic Blood Pressure (msSBP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Sitting Diastolic Blood Pressure (msDBP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Sitting Pulse Pressure (msPP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Arterial Pressure (MAP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean 24-hour Systolic Blood Pressure (maSBP) — Baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean 24-hour Diastolic Blood Pressure (maDBP) — Baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean 24-hour Ambulatory Pulse Pressure (maPP) — Baseline, 12 weeks, and 52 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":true},"controlled_terms":["Hypertension","LCZ696","Olmesartan","LCZ696 matching placebo","Olmesartan matching placebo","amlodipine","hydrochlorothiazide"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: arterial stiffness.","quality_checked_at":"2026-09-25T06:10:57.79658+00:00","duplicate_cluster_key":"id:nct01692301","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2012-12-01 to 2015-04-01","comparator":"Olmesartan","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:49.956Z","intervention":["LCZ696","Olmesartan","LCZ696 matching placebo","Olmesartan matching placebo","amlodipine","hydrochlorothiazide"],"participants":454,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change From Baseline in Mean Central Aortic Systolic Pressure (CASP) at 12 Weeks — baseline, 12 weeks","Change From Baseline in Mean Central Pulse (CPP) Pressure — Baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Pulse Wave Velocity (PWV) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Central Aortic Systolic Pressure (CASP) at 52 Weeks — baseline, 52 weeks","Change From Baseline in Mean Sitting Systolic Blood Pressure (msSBP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Sitting Diastolic Blood Pressure (msDBP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Sitting Pulse Pressure (msPP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean Arterial Pressure (MAP) — baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean 24-hour Systolic Blood Pressure (maSBP) — Baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean 24-hour Diastolic Blood Pressure (maDBP) — Baseline, 12 weeks, and 52 weeks","Change From Baseline in Mean 24-hour Ambulatory Pulse Pressure (maPP) — Baseline, 12 weeks, and 52 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: arterial stiffness.","Abstract contains controlled term: arterial stiffness.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36895","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}