{"type":"trials","record":{"id":36989,"source_id":"clinicaltrials-gov","external_id":"NCT05807243","title":"Description of Immunosenescence Biomarkers and Nutritional Intervention to Evaluate the Implementation of Digital Tools","brief_summary":"Descriptive comparative study of immunosenescence markers and their association with nutritional, metabolic, metabolomic and genetic characteristics in young (control), senior (age-associated immunosenescence), and populations susceptible to premature immunosenescence such as obese patients, cancer patients and patients who developed severe forms of COVID19 or persistent COVID19. In one of these populations of premature immunosenescence, the population group with overweight or obesity, a prospective and cross-sectional nutritional intervention study is proposed, with data capture and monitoring using digital tools, to evaluate the evolution of immunosenescence markers and assess more objectively and effectively the nutritional status and help in making personalised decisions thanks to the application of these tools. This nutritional intervention will be focused on controlled and safe weight loss that will allow the capture of a large number of variables on lifestyle and dietary habits, nutritional assessment, biochemical, metabolic, genetic, metagenomic, lipidomic and metabolomic markers measured statically and also continuously.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"IMDEA Food","enrollment":500,"countries":["Spain"],"start_date":"2022-05-09","completion_date":"2022-11-18","last_update_date":"2023-04-11","source_url":"https://clinicaltrials.gov/study/NCT05807243","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:28.303939+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":"Group 3 - Young healthy population; Group 4 - Senior population; Group 5 - Oncological population; Group 6 - COVID-19 population","organization":"IMDEA Food","interventions":["Dietary intervention for healthy weight loss"],"registry_source":"ClinicalTrials.gov","outcome_measures":["BMI — 1 month","Blood Glucose — 1 month","Concentration of interstitial glucose — 15 days","Blood lymphocytes — 12 months","Weight — 1 month","WC — 1 month","Body composition — 1 month","Blood pressure — 1 month","Heart Rate — 1 month","Dietary intake — 1 month","Physical activity — 1 month","Sleep — 1 month","Mental health state — 1 month","Cognition — 1 month","Health status and quality of life — 1 month","Percentage of glycated haemoglobin — 1 month","Total cholesterol — 1 month","Low density lipoprotein (LDL) — 1 month","High density lipoprotein (HDL) — 1 month","Triglycerides — 1 month"],"design_description":"RANDOMIZED · CROSSOVER · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Chronic Disease","Dietary intervention for healthy weight loss"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: immunosenescence.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct05807243","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-05-09 to 2022-11-18","comparator":"Group 3 - Young healthy population; Group 4 - Senior population; Group 5 - Oncological population; Group 6 - COVID-19 population","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.089Z","intervention":["Dietary intervention for healthy weight loss"],"participants":500,"study_design":"RANDOMIZED · CROSSOVER · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["BMI — 1 month","Blood Glucose — 1 month","Concentration of interstitial glucose — 15 days","Blood lymphocytes — 12 months","Weight — 1 month","WC — 1 month","Body composition — 1 month","Blood pressure — 1 month","Heart Rate — 1 month","Dietary intake — 1 month","Physical activity — 1 month","Sleep — 1 month","Mental health state — 1 month","Cognition — 1 month","Health status and quality of life — 1 month","Percentage of glycated haemoglobin — 1 month","Total cholesterol — 1 month","Low density lipoprotein (LDL) — 1 month","High density lipoprotein (HDL) — 1 month","Triglycerides — 1 month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Abstract contains controlled term: immunosenescence.","Title supplies longevity context: senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36989","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}