{"type":"trials","record":{"id":36995,"source_id":"clinicaltrials-gov","external_id":"NCT04534049","title":"The Influence of Different Types of Physical Exercise on Immunosenescence in Elderly Persons","brief_summary":"This study aims to identify the mechanisms by which physical exercise can counter inflammation and improve immune function in older persons. These mechanisms will be investigated to develop exercise-based/derived strategies to improve recovery of older patients suffering from immunosenescence and/or immune suppression. In this randomized controlled trial, the effects of resistance exercise (RE) on inflammation and chronic low-grade inflammation (CLIP) will be investigated. The investigators expect that exercise-induced changes in immunosenescence will be reflected by changes in the various domains of interest: 1) the expression of immunosenescence-related genes in PMBC, in circulating markers of inflammation and in PMBC behaviour following LPS stimulation, 2) the proportion of circulating PMBC showing surface and/or intracellular markers for cell senescence, and 3) markers reflecting alterations at the level of the extracellular matrix. Additionally, the investigators want to verify whether 1) resistance exercise improves inflammation and immunosenescence in skin tissue, and 2) resistance exercise improves the stress response in skin tissue after an in-vivo inflammatory challenge by saline injection. The results of this project will allow us to provide new insights in the complex interaction between physical exercise and immunosenescence as well as to present evidence-based guidelines for exercise in elderly persons to counter CLIP","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Vrije Universiteit Brussel","enrollment":300,"countries":["Belgium"],"start_date":"2011-12-01","completion_date":"2024-12-01","last_update_date":"2022-01-26","source_url":"https://clinicaltrials.gov/study/NCT04534049","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:28.303939+00:00","last_seen_at":"2026-09-25T06:15:20.281+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Vrije Universiteit Brussel","interventions":["Intensive Strength Training (IST)","Strength Endurance Training (SET)","Flexibility Training (FT)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Peripheral blood of older adults will be investigated by qPCR to reveal changes in the inflammatory profile — Change fr…"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE","source_has_results":false},"controlled_terms":["Healthy Aged Volunteers","Intensive Strength Training (IST)","Strength Endurance Training (SET)","Flexibility Training (FT)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: immunosenescence.","quality_checked_at":"2026-09-25T06:15:30.843286+00:00","duplicate_cluster_key":"id:nct04534049","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2011-12-01 to 2024-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:20.378Z","intervention":["Intensive Strength Training (IST)","Strength Endurance Training (SET)","Flexibility Training (FT)"],"participants":300,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Peripheral blood of older adults will be investigated by qPCR to reveal changes in the inflammatory profile — Change fr…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Abstract contains controlled term: immunosenescence.","Title supplies longevity context: senescence, elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36995","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}