{"type":"trials","record":{"id":37003,"source_id":"clinicaltrials-gov","external_id":"NCT02554188","title":"Fasting-mimicking Diet and Immunosenescence","brief_summary":"The objective of this study is to test a Fasting-Mimicking Diet (FMD) for its efficacy on improving immune response to flu vaccination in an older adult population (50-75 years of age).","overall_status":"Withdrawn","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"University of Southern California","enrollment":0,"countries":[],"start_date":"2019-05-01","completion_date":"2019-05-01","last_update_date":"2019-10-30","source_url":"https://clinicaltrials.gov/study/NCT02554188","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:28.303939+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 75 Years","comparator":"Control","organization":"University of Southern California","interventions":["Seasonal influenza (flu) vaccine","Diet"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Anti-Influenza Serum antibody titers 4 weeks after flu vaccination — 3 months","Body composition changes — 3 months","Physiological changes — 3-6 months","Health outcomes — 3-12 months","Flu incidence and severity questionnaire — up to 1 years","Dry eye surveys — up to 1 years"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","source_has_results":false},"controlled_terms":["Immunosenescence","Seasonal influenza (flu) vaccine","Diet"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: immunosenescence.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct02554188","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-05-01 to 2019-05-01","comparator":"Control","confidence":"structured-source","population":"ALL · 50 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.091Z","intervention":["Seasonal influenza (flu) vaccine","Diet"],"participants":0,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Anti-Influenza Serum antibody titers 4 weeks after flu vaccination — 3 months","Body composition changes — 3 months","Physiological changes — 3-6 months","Health outcomes — 3-12 months","Flu incidence and severity questionnaire — up to 1 years","Dry eye surveys — up to 1 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Source terminology contains: immunosenescence.","Title supplies longevity context: senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/37003","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}