{"type":"trials","record":{"id":37011,"source_id":"clinicaltrials-gov","external_id":"NCT02375711","title":"Immunosenescence and Hepatitis B Virus (HBV) Vaccine Efficacy in Chronic Renal Disease Patient","brief_summary":"The aim of this study is to investigate the role of immunosenescence in the HBV vaccination response in patients with renal insufficiency.","overall_status":"Terminated","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Centre Hospitalier Universitaire de Besancon","enrollment":20,"countries":["France"],"start_date":"2014-03-01","completion_date":"2017-09-01","last_update_date":"2018-04-05","source_url":"https://clinicaltrials.gov/study/NCT02375711","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:28.303939+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":"IVVI","age_range":"18 Years to 85 Years","comparator":null,"organization":"Centre Hospitalier Universitaire de Besancon","interventions":["Blood sample"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cluster of Differentiation (CD) 8+ CD 57+ CD 28- / CD 8+ T lymphocytes Ratio in Peripheral Blood — 13 months","Calculated Creatinine Clearance (Cockcroft-Gault Equation) — 13 months","Interferon gamma and Interleukin-10 production of Peripheral blood T lymphocytes — 13 months","Percentage of Lymphocytes subpopulations in Peripheral Blood Mononuclear Cells — 13 months","T-cell receptor excision circle (TREC) level in peripheral blood mononuclear cells (PBMC) — 13 months"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":false},"controlled_terms":["Chronic Renal Disease","Blood sample"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: immunosenescence.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct02375711","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-03-01 to 2017-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.093Z","intervention":["Blood sample"],"participants":20,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cluster of Differentiation (CD) 8+ CD 57+ CD 28- / CD 8+ T lymphocytes Ratio in Peripheral Blood — 13 months","Calculated Creatinine Clearance (Cockcroft-Gault Equation) — 13 months","Interferon gamma and Interleukin-10 production of Peripheral blood T lymphocytes — 13 months","Percentage of Lymphocytes subpopulations in Peripheral Blood Mononuclear Cells — 13 months","T-cell receptor excision circle (TREC) level in peripheral blood mononuclear cells (PBMC) — 13 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Abstract contains controlled term: immunosenescence.","Title supplies longevity context: senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/37011","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}