{"type":"trials","record":{"id":37092,"source_id":"clinicaltrials-gov","external_id":"NCT02696889","title":"Rejuvenation of Premature Ovarian Failure With Stem Cells","brief_summary":"The ROSE-1 study is designed to determine the efficacy of bone marrow derived stem cell therapy on ovarian function recovery in subjects with idiopathic and other types of premature or primary ovarian failure (POF or POI) and low ovarian reserves.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Illinois at Chicago","enrollment":3,"countries":["United States"],"start_date":"2016-02-06","completion_date":"2021-05-06","last_update_date":"2021-09-23","source_url":"https://clinicaltrials.gov/study/NCT02696889","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:29.060472+00:00","last_seen_at":"2026-09-25T06:15:10.83+00:00","metadata":{"sex":"FEMALE","acronym":"ROSE-1","age_range":"18 Years","comparator":null,"organization":"University of Illinois at Chicago","interventions":["ROSE-1 Protocol"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Improved diagnostic hormonal levels — 18 months","Resumption of menses — 18 months","Improved clinical hormone levels — 18 months","Achievement of pregnancy — 18 months"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Primary Ovarian Insufficiency","Low Ovarian Reserve","Premature Ovarian Failure","ROSE-1 Protocol"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-25T06:15:11.94354+00:00","duplicate_cluster_key":"id:nct02696889","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-02-06 to 2021-05-06","comparator":null,"confidence":"structured-source","population":"FEMALE · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:10.843Z","intervention":["ROSE-1 Protocol"],"participants":3,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Improved diagnostic hormonal levels — 18 months","Resumption of menses — 18 months","Improved clinical hormone levels — 18 months","Achievement of pregnancy — 18 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Abstract contains controlled term: stem cell.","Title supplies longevity context: rejuvenation.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/37092","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}