{"type":"trials","record":{"id":37126,"source_id":"clinicaltrials-gov","external_id":"NCT01384526","title":"Investigating the Impact of Tamoxifen Therapy on Ovarian Aging","brief_summary":"Ovarian toxicity is a well-described side effect of traditional chemotherapy in premenopausal women receiving treatment for early stage breast cancer. However, the impact of long-term endocrine therapy on ovarian function is not established, and to our knowledge, has never been directly studied. Understanding the effects of hormone therapy on ovarian aging will help breast cancer patients of reproductive age make more informed and empowered decisions regarding their treatment. The purpose of this study is to explore the relationship between tamoxifen therapy and ovarian aging. Patients will be identified through the UCSF Cancer Registry and California Pacific Medical Center Cancer Registry and will be evaluated based on age and menopausal status. Women who read about the study from clinicaltrials.gov and contact the study coordinator will also be considered for enrollment. The age of menopause onset will be assessed through surveys and will be compared to the accepted national average age of natural menopause. Biomarkers of ovarian reserve will be assessed in premenopausal women between ages 25-45 and will be compared to those of healthy age- and ethnicity-matched premenopausal controls from an ongoing RO1- funded prospective longitudinal ovarian aging (OVA) study.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of California, San Francisco","enrollment":266,"countries":["United States"],"start_date":"2011-06-01","completion_date":"2015-03-01","last_update_date":"2015-03-09","source_url":"https://clinicaltrials.gov/study/NCT01384526","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:29.060472+00:00","last_seen_at":"2026-09-25T06:15:10.83+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"25 Years","comparator":null,"organization":"University of California, San Francisco","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["age of menopause onset — assessed at time of reproductive history survey (30 minutes long, one-time assessment)","biomarkers of ovarian reserve — assessed at time of ultrasound and blood draw (single day appointment, 1 hour)","reproductive history — assessed at time of reproductive history survey (30 minutes long, one-time assessment)","lifestyle factors, medical history, and demographics — assessed at time of reproductive history survey (30 minutes long…"],"design_description":null,"source_has_results":false},"controlled_terms":["Breast Cancer","Fertility"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: ovarian aging.","quality_checked_at":"2026-09-25T06:15:11.94354+00:00","duplicate_cluster_key":"id:nct01384526","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2011-06-01 to 2015-03-01","comparator":null,"confidence":"structured-source","population":"FEMALE · 25 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:10.851Z","intervention":[],"participants":266,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["age of menopause onset — assessed at time of reproductive history survey (30 minutes long, one-time assessment)","biomarkers of ovarian reserve — assessed at time of ultrasound and blood draw (single day appointment, 1 hour)","reproductive history — assessed at time of reproductive history survey (30 minutes long, one-time assessment)","lifestyle factors, medical history, and demographics — assessed at time of reproductive history survey (30 minutes long…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"ovarian-aging","is_published":true,"match_reasons":["Title contains controlled term: ovarian aging.","Abstract contains controlled term: ovarian aging, ovarian reserve.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Ovarian ageing","slug":"ovarian-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/37126","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}