{"type":"trials","record":{"id":37131,"source_id":"clinicaltrials-gov","external_id":"NCT01665716","title":"Ovarian Ageing in Type 1 Diabetes Mellitus","brief_summary":"In healthy women, early menopause is an event that is associated with the exacerbation of several risk factors of cardiovascular and skeletal disease. The occurrence of an early menopause may have even greater impact in women with type 1 diabetes mellitus (DM-1). A small number of studies has demonstrated that DM-1 patients experience cycle irregularity and menopause at a younger age compared to controls. In addition, initial studies have suggested that also in regular cycling DM-1 women a decreased ovarian reserve status for age is present. The explanation for this early decay in ovarian reserve in DM-1 patients remains unknown. Next to auto immunity, vascular factors may be possible contributors to accelerated ovarian ageing in DM-1 patients. Confirmation of more accelerated ovarian ageing in DM-1 women is urgently needed in view of the added risk factors outlined above. Also, the mechanisms behind the advanced ovarian ageing, with focus on vascular factors, may shed new light on our understanding of the ovarian ageing process per se.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"UMC Utrecht","enrollment":290,"countries":["Netherlands"],"start_date":"2011-07-01","completion_date":"2014-03-01","last_update_date":"2014-04-11","source_url":"https://clinicaltrials.gov/study/NCT01665716","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:29.060472+00:00","last_seen_at":"2026-09-25T06:15:10.83+00:00","metadata":{"sex":"FEMALE","acronym":"OVADIA","age_range":"18 Years","comparator":null,"organization":"UMC Utrecht","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["OVADIA 1: serum AMH level — Blood withdrawel once at screening","OVADIA 2: Age at menopause — Assesed once in questionnaire"],"design_description":null,"source_has_results":false},"controlled_terms":["Type 1 Diabetes Mellitus"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: ovarian ageing.","quality_checked_at":"2026-09-25T06:15:11.94354+00:00","duplicate_cluster_key":"id:nct01665716","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2011-07-01 to 2014-03-01","comparator":null,"confidence":"structured-source","population":"FEMALE · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:10.852Z","intervention":[],"participants":290,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["OVADIA 1: serum AMH level — Blood withdrawel once at screening","OVADIA 2: Age at menopause — Assesed once in questionnaire"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"ovarian-aging","is_published":true,"match_reasons":["Title contains controlled term: ovarian ageing.","Abstract contains controlled term: ovarian ageing, ovarian reserve.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Ovarian ageing","slug":"ovarian-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/37131","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}