{"type":"trials","record":{"id":37339,"source_id":"clinicaltrials-gov","external_id":"NCT04641013","title":"Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE)","brief_summary":"The ARCHIVE study is an observational longitudinal cohort study of people with and without HIV who are over the age of 55. The duration of the study is planned for 10 years, with study visits every 1-2 years. The objectives of the study are to evaluate genomic and other factors associated with aging, stratified by HIV status.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Kirby Institute","enrollment":446,"countries":["Australia"],"start_date":"2017-12-05","completion_date":"2027-12-04","last_update_date":"2020-11-23","source_url":"https://clinicaltrials.gov/study/NCT04641013","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:32.574707+00:00","last_seen_at":"2026-09-25T06:15:18.072+00:00","metadata":{"sex":null,"acronym":"ARCHIVE","age_range":null,"comparator":null,"organization":"Kirby Institute","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Proportion of participants with at least one somatic mutation associated with clonal haematopoiesis — 2017-2019","Median and natural log-transformed Interleukin-6 — 2017-2019","Median (IQR) and natural log-transformed C-reactive protein and Cystatin C; D-dimer >0.27 — 2017-2019","Median (IQR) and natural log-transformed Haemoglobin — 2017-2019","Median (IQR) and natural log-transformed White blood cell count, Median (IQR) and natural log-transformed Neutrophil co…","natural log-transformed Mean corpuscular volume — 2017-2019","natural log transformed Red Cell distribution width — 2017-2019","Proportion of participants with diagnosed cardiovascular conditions, any malignancy, haematologic malignancies — 2017-2…"],"design_description":null,"source_has_results":false},"controlled_terms":["HIV Infections","Aging"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: clonal haematopoiesis.","quality_checked_at":"2026-09-25T06:15:18.821558+00:00","duplicate_cluster_key":"id:nct04641013","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-12-05 to 2027-12-04","comparator":null,"confidence":"structured-source","population":null,"provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:18.089Z","intervention":[],"participants":446,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Proportion of participants with at least one somatic mutation associated with clonal haematopoiesis — 2017-2019","Median and natural log-transformed Interleukin-6 — 2017-2019","Median (IQR) and natural log-transformed C-reactive protein and Cystatin C; D-dimer >0.27 — 2017-2019","Median (IQR) and natural log-transformed Haemoglobin — 2017-2019","Median (IQR) and natural log-transformed White blood cell count, Median (IQR) and natural log-transformed Neutrophil co…","natural log-transformed Mean corpuscular volume — 2017-2019","natural log transformed Red Cell distribution width — 2017-2019","Proportion of participants with diagnosed cardiovascular conditions, any malignancy, haematologic malignancies — 2017-2…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"clonal-hematopoiesis","is_published":true,"match_reasons":["Title contains controlled term: clonal haematopoiesis.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Clonal haematopoiesis","slug":"clonal-hematopoiesis"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/37339","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}