{"type":"trials","record":{"id":38,"source_id":"clinicaltrials-gov","external_id":"NCT03308747","title":"Inflammaging and Muscle Protein Metabolism","brief_summary":"The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional impairments. According to studies performed in animals and cell cultures increased concentrations of pro-inflammatory cytokines such as IL-6 and TNF-α as well as increased levels of hs-CRP lead to elevated protein degradation through proteasome activation and reduced muscle protein synthesis (MPS) via downregulation of the Akt-mTOR signaling pathway. However, evidence regarding the effects of inflammaging on skeletal muscle mass in humans is lacking. Thus, the present study will compare proteasome activation and the protein synthetic response in the fasted and postprandial period between older adults with increased systemic inflammation and their healthy control counterparts.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Thessaly","enrollment":44,"countries":["Greece"],"start_date":"2017-09-01","completion_date":"2018-05-30","last_update_date":"2018-07-19","source_url":"https://clinicaltrials.gov/study/NCT03308747","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:58.543517+00:00","last_seen_at":"2026-09-25T06:05:37.656+00:00","metadata":{"sex":"MALE","acronym":null,"age_range":"63 Years to 75 Years","comparator":"Low systemic inflammation","organization":"University of Thessaly","interventions":["Instantized Whey Protein Isolate"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Systemic inflammation — At baseline.","Change in muscle protein synthesis (MPS) — At baseline and 180 min following protein ingestion.","Change in intracellular signaling proteins in muscle — At baseline and 180 min following protein ingestion.","Change in proteasome activities in muscle — At baseline and 180 min following protein ingestion.","Change in protein expression level of proteasome subunits — At baseline and 180 min following protein ingestion.","Resting metabolic rate (RMR) — At baseline.","Physical activity — Over a 7-day period at baseline.","Dietary intake — Over a 7-day period at baseline.","Reduced glutathione in blood — At baseline.","Oxidized glutathione in blood — At baseline.","Protein carbonyls in serum — At baseline.","Total antioxidant capacity — At baseline.","Malondialdehyde in serum — At baseline.","White blood cell count in blood — At baseline.","Insulin sensitivity — At baseline.","Glucose concentration in blood — At baseline and at 30 min, 60 min, 90 min, 120 min, 150 min and 180 min following prot…","Insulin concentration in blood — At baseline and at 30 min, 60 min, 90 min, 120 min, 150 min and 180 min following prot…","Body composition — At baseline","Body Mass Index (BMI) — At baseline","Skeletal muscle index — At baseline"],"design_description":"NON RANDOMIZED · PARALLEL · BASIC SCIENCE · DOUBLE","source_has_results":false},"controlled_terms":["Inflammaging","Sarcopenia","Instantized Whey Protein Isolate"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: inflammaging.","quality_checked_at":"2026-09-25T06:05:39.423355+00:00","duplicate_cluster_key":"id:nct03308747","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-09-01 to 2018-05-30","comparator":"Low systemic inflammation","confidence":"structured-source","population":"MALE · 63 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:37.673Z","intervention":["Instantized Whey Protein Isolate"],"participants":44,"study_design":"NON RANDOMIZED · PARALLEL · BASIC SCIENCE · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Systemic inflammation — At baseline.","Change in muscle protein synthesis (MPS) — At baseline and 180 min following protein ingestion.","Change in intracellular signaling proteins in muscle — At baseline and 180 min following protein ingestion.","Change in proteasome activities in muscle — At baseline and 180 min following protein ingestion.","Change in protein expression level of proteasome subunits — At baseline and 180 min following protein ingestion.","Resting metabolic rate (RMR) — At baseline.","Physical activity — Over a 7-day period at baseline.","Dietary intake — Over a 7-day period at baseline.","Reduced glutathione in blood — At baseline.","Oxidized glutathione in blood — At baseline.","Protein carbonyls in serum — At baseline.","Total antioxidant capacity — At baseline.","Malondialdehyde in serum — At baseline.","White blood cell count in blood — At baseline.","Insulin sensitivity — At baseline.","Glucose concentration in blood — At baseline and at 30 min, 60 min, 90 min, 120 min, 150 min and 180 min following prot…","Insulin concentration in blood — At baseline and at 30 min, 60 min, 90 min, 120 min, 150 min and 180 min following prot…","Body composition — At baseline","Body Mass Index (BMI) — At baseline","Skeletal muscle index — At baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"chronic-inflammation","is_published":true,"match_reasons":["Title contains controlled term: inflammaging.","Abstract contains controlled term: inflammaging.","Source terminology contains: inflammaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Chronic inflammation","slug":"chronic-inflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/38","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}