{"type":"trials","record":{"id":384,"source_id":"clinicaltrials-gov","external_id":"NCT07572266","title":"Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults","brief_summary":"Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments to compromise intrinsic capacity and healthspan. Exercise is the only multipotent treatment with promise to mitigate many of the aging hallmarks, but there is substantial variability in individual exercise responsiveness. Thus, the investigators approach to boosting exercise responsiveness in aging is to combine an exercise training prescription containing both endurance and resistance training (in alignment with DHHS guidelines) with a nitrate-enriched dietary supplement to augment the cellular, tissue, and systemic adaptations that induce myriad health benefits of exercise in older adults.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Florida Institute for Human and Machine Cognition","enrollment":226,"countries":["United States"],"start_date":"2026-11-01","completion_date":"2031-05-01","last_update_date":"2026-08-10","source_url":"https://clinicaltrials.gov/study/NCT07572266","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:03.776617+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"BOOST-X","age_range":"60 Years","comparator":"Placebo Group","organization":"Florida Institute for Human and Machine Cognition","interventions":["Nitrate enriched beetroot juice","Nitrate depleted beetroot juice","12 week of combined exercise training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Assess the clinical impact of nitrate supplementation on a proportion of older adults attaining exercise-induced health…","Cardiorespiratory demand during submaximal cycle exercise. — 12 weeks","Neuromuscular fatiguability during isometric holds. — 12 weeks","10 meter max gait speed. — 12 weeks","modified Balance Error Scoring System (mBESS) — 12 weeks","NIH PROMIS Physical Function SF — 12 weeks","NIH PROMIS Fatigue SF — 12 weeks"],"design_description":"RANDOMIZED · SEQUENTIAL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Aging Well","Healthy Aging","Nitrate enriched beetroot juice","Nitrate depleted beetroot juice","12 week of combined exercise training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct07572266","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-11-01 to 2031-05-01","comparator":"Placebo Group","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.258Z","intervention":["Nitrate enriched beetroot juice","Nitrate depleted beetroot juice","12 week of combined exercise training"],"participants":226,"study_design":"RANDOMIZED · SEQUENTIAL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Assess the clinical impact of nitrate supplementation on a proportion of older adults attaining exercise-induced health…","Cardiorespiratory demand during submaximal cycle exercise. — 12 weeks","Neuromuscular fatiguability during isometric holds. — 12 weeks","10 meter max gait speed. — 12 weeks","modified Balance Error Scoring System (mBESS) — 12 weeks","NIH PROMIS Physical Function SF — 12 weeks","NIH PROMIS Fatigue SF — 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/384","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}