{"type":"trials","record":{"id":38641,"source_id":"clinicaltrials-gov","external_id":"NCT06618469","title":"Effects of Resistance Training Programes At Different Intensities on Musculoskeletal, Metabolic, Lipid, Immunological, Inflammatory, Well-being and Functional Parameters in Older Adults.","brief_summary":"The aging of the global population is recognized by the World Health Organization (WHO) as a major issue due to the disabilities and comorbidities related to this process, with women being the gender most affected. Due to the physiological and psychological age associated declines, physical activity and exercise are proven strategies for reducing the impact of aging. However, it is still unknown what kind of training program could be the most effective in reversing deleterious age-related changes in older adults. Regarding this, the type of training intensity and exercise modality are two key training parameters in exercise programming, and, therefore, different adaptations could be induced in older adults through the modification of these parameters. Furthermore, the type of training device is a significant factor and can act as a barrier or facilitator in older adults\\' participation in physical activities and exercise programs. Therefore, the research project primary goals are to compare the effects of resistance training programes performed at different intensities and materials during 32 weeks on a variety of physiological parameters in older adults.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Valencia","enrollment":320,"countries":["Spain"],"start_date":"2014-05-01","completion_date":"2015-07-01","last_update_date":"2024-10-01","source_url":"https://clinicaltrials.gov/study/NCT06618469","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:10.04816+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Control group","organization":"University of Valencia","interventions":["Elastic band-based resistance training program at high intensity (HI)","Elastic band-based resistance training program at moderate-high intensity (MHI-bands)","Elastic band-based resistance training program at moderate intensity (MI)","Elastic tubes-based resistance training program at moderate-high intensity (MHI-tubes)","Water-based resistance training program at moderate intensity (WMI)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in DNA oxidative stress — Baseline and 16 weeks","Change in lipid peroxidation — Baseline and 16 weeks","Change in protein oxidation — Baseline and 16 weeks","Change in antioxidants enzymes-Superoxid dismutase — Baseline and 16 weeks","Change in antioxidants enzymes-reduced glutathione — Baseline and 16 weeks","Change in antioxidants enzymes- Glutathione peroxidase — Baseline and 16 weeks","Change in antioxidants enzymes-oxidized glutathione — Baseline and 16 weeks","Change in antioxidants enzymes-Catalase — Baseline and 16 weeks","Change in inflammatory profile — Baseline, 16 and 32 weeks","Change in renal and hepatic profile — Baseline, 16 and 32 weeks","Change in metabolic profile-glycosylated hemoglobin A1C — Baseline, 16 and 32 weeks","Change in metabolic profile-basal glucose — Baseline, 16 and 32weeks","Change in immune profile-Platelet counts — Baseline, 16 and 32 weeks","Change in immune profile-plateletcrit — Baseline, 16 and 32 weeks","Change in immune profile-mean platelet volum — Baseline, 16 and 32 weeks","Change in immune profile-platelet distribution width — Baseline, 16 and 32 weeks","Change in immune profile-leukocites — Baseline, 16 and 32 weeks","Change in immune profile- neutrophils — Baseline, 16 and 32 weeks","Change in immune profile-lymphocytes — Baseline, 16 and 32 weeks","Change in immune profile-monocytes — Baseline, 16 and 32 weeks"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Elastic band-based resistance training program at high intensity (HI)","Elastic band-based resistance training program at moderate-high intensity (MHI-bands)","Elastic band-based resistance training program at moderate intensity (MI)","Elastic tubes-based resistance training program at moderate-high intensity (MHI-tubes)","Water-based resistance training program at moderate intensity (WMI)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct06618469","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-05-01 to 2015-07-01","comparator":"Control group","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.448Z","intervention":["Elastic band-based resistance training program at high intensity (HI)","Elastic band-based resistance training program at moderate-high intensity (MHI-bands)","Elastic band-based resistance training program at moderate intensity (MI)","Elastic tubes-based resistance training program at moderate-high intensity (MHI-tubes)","Water-based resistance training program at moderate intensity (WMI)"],"participants":320,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in DNA oxidative stress — Baseline and 16 weeks","Change in lipid peroxidation — Baseline and 16 weeks","Change in protein oxidation — Baseline and 16 weeks","Change in antioxidants enzymes-Superoxid dismutase — Baseline and 16 weeks","Change in antioxidants enzymes-reduced glutathione — Baseline and 16 weeks","Change in antioxidants enzymes- Glutathione peroxidase — Baseline and 16 weeks","Change in antioxidants enzymes-oxidized glutathione — Baseline and 16 weeks","Change in antioxidants enzymes-Catalase — Baseline and 16 weeks","Change in inflammatory profile — Baseline, 16 and 32 weeks","Change in renal and hepatic profile — Baseline, 16 and 32 weeks","Change in metabolic profile-glycosylated hemoglobin A1C — Baseline, 16 and 32 weeks","Change in metabolic profile-basal glucose — Baseline, 16 and 32weeks","Change in immune profile-Platelet counts — Baseline, 16 and 32 weeks","Change in immune profile-plateletcrit — Baseline, 16 and 32 weeks","Change in immune profile-mean platelet volum — Baseline, 16 and 32 weeks","Change in immune profile-platelet distribution width — Baseline, 16 and 32 weeks","Change in immune profile-leukocites — Baseline, 16 and 32 weeks","Change in immune profile- neutrophils — Baseline, 16 and 32 weeks","Change in immune profile-lymphocytes — Baseline, 16 and 32 weeks","Change in immune profile-monocytes — Baseline, 16 and 32 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/38641","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}