{"type":"trials","record":{"id":38821,"source_id":"clinicaltrials-gov","external_id":"NCT01177189","title":"Oxidative Stress Links Aging, Activity, and Mobility Limitation","brief_summary":"The purpose of this study is to understand why and how oxidative stress negatively impacts mobility in the elderly, and to determine whether antioxidant supplements can increase vascular health and mobility.","overall_status":"Terminated","phases":[],"study_type":"INTERVENTIONAL","sponsor":"VA Office of Research and Development","enrollment":87,"countries":[],"start_date":"2011-07-01","completion_date":"2017-07-03","last_update_date":"2019-02-21","source_url":"https://clinicaltrials.gov/study/NCT01177189","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:10.04816+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"VA Office of Research and Development","interventions":["Vitamins C, E, and alpha lipoic acid"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Vascular Function (i.e. % Flow Mediated Vasodilation) — 8 weeks","Exercise-induced Oxidative Stress (i.e. Free Radical Concentrations and Levels of Lipid Peroxidation) — 8 weeks","Vascular Function Following the Antioxidant Intervention — 8 weeks"],"design_description":"RANDOMIZED · CROSSOVER · TREATMENT · TRIPLE","source_has_results":true},"controlled_terms":["Aging","Vitamins C, E, and alpha lipoic acid"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: oxidative stress.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct01177189","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2011-07-01 to 2017-07-03","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.485Z","intervention":["Vitamins C, E, and alpha lipoic acid"],"participants":87,"study_design":"RANDOMIZED · CROSSOVER · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Vascular Function (i.e. % Flow Mediated Vasodilation) — 8 weeks","Exercise-induced Oxidative Stress (i.e. Free Radical Concentrations and Levels of Lipid Peroxidation) — 8 weeks","Vascular Function Following the Antioxidant Intervention — 8 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Abstract contains controlled term: oxidative stress.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/38821","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}