{"type":"trials","record":{"id":38826,"source_id":"clinicaltrials-gov","external_id":"NCT03455179","title":"Effects of Slow-speed Traditional Resistance Training, High-speed Resistance Training and Multicomponent Training With Variable Resistances on Molecular, Body Composition, Neuromuscular, Physical Function and Quality of Life Variables in Older Adults.","brief_summary":"Human aging is characterized by a progressive deterioration of multiple physiologic systems, with marked decreases in skeletal muscle mass, muscle strength, physical function and quality of life beginning in the sixth decade in life. These deleterious modifications have a significant impact upon mobility and ability to undertake daily living activities in elderly people. If we consider that, according to current projections, the proportion of the European population over 65 years will increase from 17% in 2010 to 30% in 2060 and that physical activity participation rates for older adults (\\>60 years) remain low, with only 16% meeting the recommendations of the American College of Sports Medicine Guidelines (11% for resistance training), we need to understand what type of training (strategy) can be the most effective for reverse physical impairments, and not only that, but which one obtains greater adherence and self-perception for contribute a healthier, active and more independent elderly population in the future. Thus, the purpose of this study is to investigate the effects of 20-week slow-speed traditional resistance training, high-speed resistance training and multicomponent training program with variable resistance (elastic bands) on molecular, body composition, neuromuscular, physical function and quality of life variables in older adults. This research also aims to evaluate if this novel types of training intervention (using variable resistances such as elastic bands in all the training programs and measure the intensity with the OMNI-RES perceived exertion specific for older adults) is feasible in this population, through analysis of adherence, intervention fidelity and self-perception reported.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Valencia","enrollment":192,"countries":["Spain"],"start_date":"2018-03-05","completion_date":"2018-07-31","last_update_date":"2018-10-24","source_url":"https://clinicaltrials.gov/study/NCT03455179","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:10.04816+00:00","last_seen_at":"2026-09-25T06:25:45.678+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Control","organization":"University of Valencia","interventions":["Slow-speed traditional resistance training","High-speed resistance training","Multicomponent training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in DNA oxidative stress — Baseline and 20 weeks","Change in lipid peroxidation — Baseline and 20 weeks","Change in protein oxidation — Baseline and 20 weeks","Change in antioxidants enzymes — Baseline and 20 weeks","Change in metabolic profile — Baseline and 20 weeks","Change in lipid profile — Baseline and 20 weeks","Change in immune profile — Baseline and 20 weeks","Change in C-reactive Protein — Baseline and 20 weeks","Change in bone metabolism — Baseline and 20 weeks","Change in muscle strength — Baseline and 20 weeks","Change in functional performance — Baseline and 20 weeks","Change in lower extremity performance — Baseline and 20 weeks","Change in 10-meters walking speed — Baseline and 20 weeks","Change in stair climbing — Baseline and 20 weeks","Change in muscle thickness — Baseline and 20 weeks","Change in pennation angle — Baseline and 20 weeks","Change in cross-sectional area — Baseline and 20 weeks","Change in fascicle length — Baseline and 20 weeks","Change in echo intensity — Baseline and 20 weeks","Change in total mass — Baseline and 20 weeks"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Slow-speed traditional resistance training","High-speed resistance training","Multicomponent training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:25:48.368501+00:00","duplicate_cluster_key":"id:nct03455179","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-03-05 to 2018-07-31","comparator":"Control","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:45.735Z","intervention":["Slow-speed traditional resistance training","High-speed resistance training","Multicomponent training"],"participants":192,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in DNA oxidative stress — Baseline and 20 weeks","Change in lipid peroxidation — Baseline and 20 weeks","Change in protein oxidation — Baseline and 20 weeks","Change in antioxidants enzymes — Baseline and 20 weeks","Change in metabolic profile — Baseline and 20 weeks","Change in lipid profile — Baseline and 20 weeks","Change in immune profile — Baseline and 20 weeks","Change in C-reactive Protein — Baseline and 20 weeks","Change in bone metabolism — Baseline and 20 weeks","Change in muscle strength — Baseline and 20 weeks","Change in functional performance — Baseline and 20 weeks","Change in lower extremity performance — Baseline and 20 weeks","Change in 10-meters walking speed — Baseline and 20 weeks","Change in stair climbing — Baseline and 20 weeks","Change in muscle thickness — Baseline and 20 weeks","Change in pennation angle — Baseline and 20 weeks","Change in cross-sectional area — Baseline and 20 weeks","Change in fascicle length — Baseline and 20 weeks","Change in echo intensity — Baseline and 20 weeks","Change in total mass — Baseline and 20 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/38826","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}