{"type":"trials","record":{"id":38891,"source_id":"clinicaltrials-gov","external_id":"NCT01962961","title":"N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults","brief_summary":"The goal of this study is to determine if n-acetylcysteine, given as PharmaNAC, reduces oxidative stress and improves vascular function in HIV-infected older adults already on HIV treatment.","overall_status":"Completed","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Indiana University","enrollment":24,"countries":["United States"],"start_date":"2013-10-01","completion_date":"2015-10-01","last_update_date":"2016-02-08","source_url":"https://clinicaltrials.gov/study/NCT01962961","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:10.04816+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":"Placebo","organization":"Indiana University","interventions":["PharmaNAC (N-acetylcysteine)","Matching placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Circulating Malondialdehyde Levels — Baseline and 8 weeks","Change in Circulating F2-isoprostane Levels — Baseline and 8 weeks","Change in Flow-mediated Dilation (FMD) of the Brachial Artery — Baseline and 8 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":true},"controlled_terms":["HIV","Endothelial Dysfunction","Oxidative Stress","PharmaNAC (N-acetylcysteine)","Matching placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: oxidative stress.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct01962961","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2013-10-01 to 2015-10-01","comparator":"Placebo","confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.498Z","intervention":["PharmaNAC (N-acetylcysteine)","Matching placebo"],"participants":24,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Circulating Malondialdehyde Levels — Baseline and 8 weeks","Change in Circulating F2-isoprostane Levels — Baseline and 8 weeks","Change in Flow-mediated Dilation (FMD) of the Brachial Artery — Baseline and 8 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Abstract contains controlled term: oxidative stress.","Source terminology contains: oxidative stress.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/38891","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}