{"type":"trials","record":{"id":38920,"source_id":"clinicaltrials-gov","external_id":"NCT00579774","title":"Effects of Glycoxidative Stress on Human Aging","brief_summary":"Advanced glycation products or AGEs are a heterogeneous group of molecules formed by exposure of tissue constituents to high levels of reducing sugars, e.g. glucose. The interaction of these compounds with extra- and intra-cellular components may account in part for several conditions related to aging. It has recently been recognized that AGEs are also formed during the preparation of food by heating, are absorbed into the circulation and become largely incorporated into tissue components. Accumulation of these exogenous substances over time may, together with those generated endogenously, contribute to the clinical manifestations and complications of aging. This is an interventional-randomized study in which we are trying to determine whether a diet low in AGE can effectively reduce circulating AGE levels, with or without altering oxidation or inflammatory markers, in a subset of both young and older subjects , over a period of 4 months. If positive results are obtained, longer-term prospective studies will be designed to determine if this intervention can affect disease outcomes in older age subjects. The study design is very simple and consists initially of obtaining a dietary history, a blood sample, 24-hour urine collection and, subsequently, of determining the effects of a low-AGE diet for 4 months on the plasma levels of these compounds in a group of healthy subjects.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Icahn School of Medicine at Mount Sinai","enrollment":438,"countries":["United States"],"start_date":"2007-01-01","completion_date":"2011-10-01","last_update_date":"2014-04-09","source_url":"https://clinicaltrials.gov/study/NCT00579774","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:10.04816+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 35 Years","comparator":"2 - Regular Diet","organization":"Icahn School of Medicine at Mount Sinai","interventions":["Low AGE Diet","Regular Diet"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Levels of AGE — Monthly","Side Effect Measurement — Monthly"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Aging","Low AGE Diet","Regular Diet"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: oxidative stress.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct00579774","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2007-01-01 to 2011-10-01","comparator":"2 - Regular Diet","confidence":"structured-source","population":"ALL · 18 Years to 35 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.502Z","intervention":["Low AGE Diet","Regular Diet"],"participants":438,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Levels of AGE — Monthly","Side Effect Measurement — Monthly"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/38920","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}