{"type":"trials","record":{"id":38944,"source_id":"clinicaltrials-gov","external_id":"NCT01775111","title":"Influence of Strength Training and Protein Supplementation on Fitness of Institutionalized Elderly","brief_summary":"The aim of this randomized, observer-blind, controlled intervention study with parallel groups is to study the effect of strength training (2x/week for 6 months) with and without additional dietary supplementation (protein-enriched) on muscle strength, function and mass, oxidative stress parameters and the immune system in elderly institutionalized persons. The participants (n = 120) are recruited from Viennese senior residencies (Kuratorium Wiener Pensionistenwohnheime). After a pre-participation screening participants will be distributed randomly but stratified by sex and age to one of the 3 intervention groups (cognitive training, strength training, strength training + supplement). Study participants are eligible if they are male or female with an age over 65 years and if their cognitive status as well as their physical fitness level allows to participate at the strength training sessions. Exclusion criteria comprise chronic diseases which contraindicate the medical training therapy, serious cardiovascular disease, diabetic retinopathy and manifest osteoporosis, medication with anticoagulants or cortisone drugs and also regular strength training during the last six months. Primary outcome measure is the change in isokinetic torque of knee extensors. Secondary outcome measures comprise anthropometric data, functional performance tests, immunological and oxidative stress parameters. The change in muscle signaling pathways will be assessed from muscle biopsies.","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Vienna","enrollment":120,"countries":["Austria"],"start_date":"2012-01-01","completion_date":null,"last_update_date":"2013-01-24","source_url":"https://clinicaltrials.gov/study/NCT01775111","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:10.04816+00:00","last_seen_at":"2026-09-25T06:20:19.667+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"University of Vienna","interventions":["Cognitive Training","Strength Training","FortiFit"],"registry_source":"ClinicalTrials.gov","outcome_measures":["change from baseline in isokinetic torque of knee extensors — baseline and 6 months","change from baseline in 6min walking test — baseline and 6 months","change from baseline in handgrip strength — baseline and 6 months","change from baseline in single leg balance stand — baseline and 6 months","change from baseline in lean body mass — baseline and 6 months","change from baseline in muscular myostatin expression — baseline and 6 months","change from baseline in DNA strand breaks — baseline and 6 months","change from baseline in high-sensitive C reactive protein — baseline and 6 months"],"design_description":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · SINGLE","source_has_results":false},"controlled_terms":["Aging","Cognitive Training","Strength Training","FortiFit"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T06:20:27.00315+00:00","duplicate_cluster_key":"id:nct01775111","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"From 2012-01-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:19.776Z","intervention":["Cognitive Training","Strength Training","FortiFit"],"participants":120,"study_design":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["change from baseline in isokinetic torque of knee extensors — baseline and 6 months","change from baseline in 6min walking test — baseline and 6 months","change from baseline in handgrip strength — baseline and 6 months","change from baseline in single leg balance stand — baseline and 6 months","change from baseline in lean body mass — baseline and 6 months","change from baseline in muscular myostatin expression — baseline and 6 months","change from baseline in DNA strand breaks — baseline and 6 months","change from baseline in high-sensitive C reactive protein — baseline and 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: strength training.","Source terminology contains: strength training.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/38944","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}