{"type":"trials","record":{"id":39096,"source_id":"clinicaltrials-gov","external_id":"NCT06746909","title":"Identification of Neuroinflammation and Neuroimaging Biomarkers Through Data Driven Artificial Intelligence Techniques for Unraveling the Heterogeneity of Aged Subjects at Risk of Dementia and to Better Inform Prevention Strategies","brief_summary":"SCD and MCI are very heterogeneous conditions, which can be prodromal to different types of dementia. The application of data driven clustering methods on neuroimaging and inflammatory data aims at identifying the features characterizing subgroups of subjects at high risk of developing overt dementia. This approach promises to develop tailored early interventions for subjects with profiles of cognitive decline correlating with high risk of progression. To this end in this project, we propose to examine in these subjects both brain structure and cerebral blood flow (CBF) through MR T1-weighted and pCASL (pseudo-continuous arterial spin labeling) imaging and the neuroinflammatory status. The latter will be done by measuring the populations of innate and adaptive immune cells, the chemokines that are required to attract these cells to their potential sites of action in the CNS, and the cytokines by means they exert their function. The analyses performed in aged subjects with MCI and in SCD, will allow identifying common mechanisms predisposing to an increased susceptibility to progression to overt cognitive decline.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"IRCCS Fondazione Stella Maris","enrollment":115,"countries":["Italy"],"start_date":"2022-02-01","completion_date":"2026-06-30","last_update_date":"2024-12-24","source_url":"https://clinicaltrials.gov/study/NCT06746909","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:14.411411+00:00","last_seen_at":"2026-09-25T06:20:07.141+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 89 Years","comparator":"MCI training; MCI no-training; healthy subjects; SCD; SCD training; SCD no-training","organization":"IRCCS Fondazione Stella Maris","interventions":["Multidomain cognitive training and physical training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Short term training effects — 7 months","Sample stratification — 7, 14 and 28 months"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["MCI","SCD","Healthy","Multidomain cognitive training and physical training"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: neuroinflammation.","quality_checked_at":"2026-09-25T06:20:08.679024+00:00","duplicate_cluster_key":"id:nct06746909","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-02-01 to 2026-06-30","comparator":"MCI training; MCI no-training; healthy subjects; SCD; SCD training; SCD no-training","confidence":"structured-source","population":"ALL · 65 Years to 89 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:07.160Z","intervention":["Multidomain cognitive training and physical training"],"participants":115,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Short term training effects — 7 months","Sample stratification — 7, 14 and 28 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"neuroinflammation","is_published":true,"match_reasons":["Title contains controlled term: neuroinflammation.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Neuroinflammation","slug":"neuroinflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39096","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}