{"type":"trials","record":{"id":39102,"source_id":"clinicaltrials-gov","external_id":"NCT03723694","title":"Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders","brief_summary":"The purpose of this study is to test the effect of a cocoa-derived dietary flavanol on brain structures and cognitive outcomes in a 12-week randomized controlled trial of 146 healthy participants, age 50-69, who will receive this cocoa derivative or a placebo. Th investigators will also examine the role of inflammation in this relationship.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Columbia University","enrollment":259,"countries":["United States"],"start_date":"2019-01-01","completion_date":"2023-06-26","last_update_date":"2024-08-27","source_url":"https://clinicaltrials.gov/study/NCT03723694","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:14.411411+00:00","last_seen_at":"2026-09-25T06:20:07.141+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 69 Years","comparator":"650 mg of Cocoapro flavanols; 0mg Cocoapro flavanols","organization":"Columbia University","interventions":["650 mg of Cocoapro flavanols","0 mg of Cocoapro flavanols"],"registry_source":"ClinicalTrials.gov","outcome_measures":["HMGB1 — 12 weeks","NFkB — 12 weeks","TNFa — 12 weeks"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · TRIPLE","source_has_results":false},"controlled_terms":["Memory Loss","Inflammation","650 mg of Cocoapro flavanols","0 mg of Cocoapro flavanols"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: neuroinflammation.","quality_checked_at":"2026-09-25T06:20:08.679024+00:00","duplicate_cluster_key":"id:nct03723694","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-01-01 to 2023-06-26","comparator":"650 mg of Cocoapro flavanols; 0mg Cocoapro flavanols","confidence":"structured-source","population":"ALL · 50 Years to 69 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:07.161Z","intervention":["650 mg of Cocoapro flavanols","0 mg of Cocoapro flavanols"],"participants":259,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["HMGB1 — 12 weeks","NFkB — 12 weeks","TNFa — 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"neuroinflammation","is_published":true,"match_reasons":["Title contains controlled term: neuroinflammation.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Neuroinflammation","slug":"neuroinflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39102","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}