{"type":"trials","record":{"id":39110,"source_id":"clinicaltrials-gov","external_id":"NCT06252844","title":"The Impact of 6-months of Resistance Training on Brain and Muscle Health in Older Adults With MCI","brief_summary":"The goal of this clinical trial is to learn about the effect of long resistance training intervention on brain and muscle health in older adults with mild cognitive impairment (MCI). The main question it aims to answer is whether progressive resistance training can prevent/delay neurodegenerative/pro-inflammatory processes that are detrimental to cognition, mobility, vitality, and mental health of older adults with MCI. Participants will undergo 6 months of supervise resistance training. Subjects in the intervention group will undergo sessions of structural and functional magnetic resonance imaging, proton magnetic resonance spectroscopy at baseline and end of intervention. Blood analyses and functional and cognitive tests will be performed at baseline after 3 months from the start of intervention and at the end of the intervention. Observations obtained from the intervention group will compare to data collected from age-matched active control group who will undergo flexibility training of lower limb muscles.","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Lithuanian Sports University","enrollment":80,"countries":["Lithuania"],"start_date":"2024-02-15","completion_date":"2025-12-01","last_update_date":"2024-02-29","source_url":"https://clinicaltrials.gov/study/NCT06252844","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:14.411411+00:00","last_seen_at":"2026-09-25T06:20:07.141+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Lithuanian Sports University","interventions":["Resistance exercise training","Active control"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Changes in intrinsic capacity — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optio…","Changes in global cognition — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optiona…","Changes in psychological assessment of depression — Baseline, Mid-intervention time (12 weeks) and Post-intervention ti…","Changes in reaction time — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optional:…","Changes in reaction accuracy — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Option…","Changes in cognitive efficiency — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Opt…","Changes in Stroop interference score — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks)…","Changes in performance on the Trail Making Test (TMT) — Baseline, Mid-intervention time (12 weeks) and Post-interventio…","Changes in sway velocity — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optional:…","Changes in dual-task cost for sway velocity — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24…","Changes in agility — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optional: follow…","Changes in lower body strength and muscular endurance — Baseline, Mid-intervention time (12 weeks) and Post-interventio…","Changes in levels of Albumin (Alb) — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks);…","Changes in levels of Hemoglobin (Hb) — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks)…","Changes in levels of C-reactive protein (CRP) — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (…","Changes in circulating levels of cytokines — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24…","Changes in circulating levels of Kynurenine — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24…","Changes in circulating levels of brain-derived neurotrophic factor (BDNF) — Baseline, Mid-intervention time (12 weeks)…","Changes in circulating levels of Insulin-like growth factor 1 (IGF-1) — Baseline, Mid-intervention time (12 weeks) and…","Changes in circulating levels of Irisin — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 wee…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Mild Cognitive Impairment","Older Adults at High Risk for MCI","Resistance exercise training","Active control"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:20:08.679024+00:00","duplicate_cluster_key":"id:nct06252844","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-02-15 to 2025-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:07.163Z","intervention":["Resistance exercise training","Active control"],"participants":80,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Changes in intrinsic capacity — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optio…","Changes in global cognition — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optiona…","Changes in psychological assessment of depression — Baseline, Mid-intervention time (12 weeks) and Post-intervention ti…","Changes in reaction time — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optional:…","Changes in reaction accuracy — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Option…","Changes in cognitive efficiency — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Opt…","Changes in Stroop interference score — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks)…","Changes in performance on the Trail Making Test (TMT) — Baseline, Mid-intervention time (12 weeks) and Post-interventio…","Changes in sway velocity — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optional:…","Changes in dual-task cost for sway velocity — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24…","Changes in agility — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks); Optional: follow…","Changes in lower body strength and muscular endurance — Baseline, Mid-intervention time (12 weeks) and Post-interventio…","Changes in levels of Albumin (Alb) — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks);…","Changes in levels of Hemoglobin (Hb) — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 weeks)…","Changes in levels of C-reactive protein (CRP) — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (…","Changes in circulating levels of cytokines — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24…","Changes in circulating levels of Kynurenine — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24…","Changes in circulating levels of brain-derived neurotrophic factor (BDNF) — Baseline, Mid-intervention time (12 weeks)…","Changes in circulating levels of Insulin-like growth factor 1 (IGF-1) — Baseline, Mid-intervention time (12 weeks) and…","Changes in circulating levels of Irisin — Baseline, Mid-intervention time (12 weeks) and Post-intervention time (24 wee…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39110","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}