{"type":"trials","record":{"id":39123,"source_id":"clinicaltrials-gov","external_id":"NCT03273335","title":"Investigating NeuroinflammaTion UnderlyIng Postoperative Brain Connectivity Changes, POCD, Delirium in Older Adults","brief_summary":"(From NIH reporter) Each year \\>16 million older Americans undergo anesthesia and surgery, and up to 40% of these patients develop postoperative cognitive dysfunction (POCD), a syndrome of postoperative thinking and memory deficits. Although distinct from delirium, POCD (like delirium) is associated with decreased quality of life, long term cognitive decline, early retirement, increased mortality, and a possible increased risk for developing dementia such as Alzheimer's disease. Understanding the etiology of POCD will likely help promote strategies to treat and/or prevent it. A dominant theory holds that brain inflammation causes POCD, but little work has directly tested this theory in humans. The preliminary data of this team strongly suggest that there is significant postoperative neuro-inflammation in older adults who develop POCD. In this K76 award, the investigators will prospectively obtain pre- and post-operative cognitive testing, fMRI imaging and CSF samples in 200 surgical patients over age 65. This will allow the investigators to evaluate the role of specific neuro-inflammatory processes in POCD and its underlying brain connectivity changes.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Duke University","enrollment":201,"countries":["United States"],"start_date":"2017-06-15","completion_date":"2022-10-21","last_update_date":"2022-11-16","source_url":"https://clinicaltrials.gov/study/NCT03273335","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:14.411411+00:00","last_seen_at":"2026-09-25T06:20:07.141+00:00","metadata":{"sex":"ALL","acronym":"INTUIT","age_range":"60 Years to 130 Years","comparator":null,"organization":"Duke University","interventions":["Millipore biomarker assay plate"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Correlation between Perioperative changes in CSF Monocytes and perioperative changes in cognition (continuous cognitive…"],"design_description":null,"source_has_results":false},"controlled_terms":["Delirium","Millipore biomarker assay plate"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: neuroinflammation.","quality_checked_at":"2026-09-25T06:20:08.679024+00:00","duplicate_cluster_key":"id:nct03273335","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-06-15 to 2022-10-21","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years to 130 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:07.166Z","intervention":["Millipore biomarker assay plate"],"participants":201,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Correlation between Perioperative changes in CSF Monocytes and perioperative changes in cognition (continuous cognitive…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"neuroinflammation","is_published":true,"match_reasons":["Title contains controlled term: neuroinflammation.","Title supplies longevity context: older adult.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Neuroinflammation","slug":"neuroinflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39123","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}