{"type":"trials","record":{"id":39208,"source_id":"clinicaltrials-gov","external_id":"NCT06520982","title":"Early Neurovascular Adaptations in Aging Women","brief_summary":"Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.","overall_status":"Recruiting","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"University of Missouri-Columbia","enrollment":64,"countries":["United States"],"start_date":"2024-09-20","completion_date":"2028-06-30","last_update_date":"2025-11-26","source_url":"https://clinicaltrials.gov/study/NCT06520982","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:15.604755+00:00","last_seen_at":"2026-09-25T06:20:09.878+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"18 Years to 70 Years","comparator":null,"organization":"University of Missouri-Columbia","interventions":["Norepinephrine","Isoproterenol","Acetylcholine","Nitroprusside","Estrogen"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Magnitude of forearm blood flow — Change from baseline during infusion"],"design_description":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Women","Sympathetic Nervous System","Aging","Blood Flow","Norepinephrine","Isoproterenol","Acetylcholine","Nitroprusside","Estrogen"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: neurovascular.","quality_checked_at":"2026-09-25T06:20:11.344357+00:00","duplicate_cluster_key":"id:nct06520982","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-20 to 2028-06-30","comparator":null,"confidence":"structured-source","population":"FEMALE · 18 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:09.892Z","intervention":["Norepinephrine","Isoproterenol","Acetylcholine","Nitroprusside","Estrogen"],"participants":64,"study_design":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Magnitude of forearm blood flow — Change from baseline during infusion"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"blood-brain-barrier-aging","is_published":true,"match_reasons":["Title contains controlled term: neurovascular.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Blood-brain barrier ageing","slug":"blood-brain-barrier-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39208","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}