{"type":"trials","record":{"id":39467,"source_id":"clinicaltrials-gov","external_id":"NCT06925035","title":"Efficacy of Combined 1927nm Thulium Fiber Laser and Supramolecular Salicylic Acid in Photoaging Treatment","brief_summary":"Purpose: 1927nm fractional thulium fiber laser (TFL) has been shown to be effective in improving skin appearance by reducing pigmentation and loss of elasticity caused by photoaging. Supramolecular salicylic acid (SSA) has been utilized for chemical peeling with rejuvenation effect. This study aims to evaluate the effectiveness and safety of combined TFL and SSA treatment for photoaging. Methods: Thirty-six patients with moderate-to-severe photoaging were enrolled and the two sides of the participants' face were randomly assigned to receive 30% SSA combined with TFL or TFL monotherapy. TFL was administered to both sides of the face on four occasions at four-week intervals, while the side receiving combined treatment additionally underwent eight chemical peels of 30% SSA fortnightly, supplemented by daily applications of 2% SSA. For the TFL-alone side, an equivalent dose of a placebo preparation was applied. The photographs, photoaging scores, melanin index (MI), erythema index (EI), skin hydration, trans-epidermal water loss (TEWL), dermal thickness, elasticity index, and skin rebound time were assessed.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","enrollment":36,"countries":["China"],"start_date":"2023-06-01","completion_date":"2023-12-31","last_update_date":"2025-04-13","source_url":"https://clinicaltrials.gov/study/NCT06925035","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"40 Years to 70 Years","comparator":"TFL-only group","organization":"Second Affiliated Hospital of Xi'an Jiaotong University","interventions":["1927nm fractional thulium fiber laser(TFL)","supramolecular salicylic acid(SSA)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["photodamage score — From enrollment to the end of treatment at 16 weeks","Melanin Index — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","Erythema Index — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","Transepidermal Water Loss — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","skin hydration — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","dermal thickness — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","elasticity index — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16."],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Photo-aged Skin","Laser","1927nm fractional thulium fiber laser(TFL)","supramolecular salicylic acid(SSA)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: photoaging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct06925035","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-06-01 to 2023-12-31","comparator":"TFL-only group","confidence":"structured-source","population":"ALL · 40 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.575Z","intervention":["1927nm fractional thulium fiber laser(TFL)","supramolecular salicylic acid(SSA)"],"participants":36,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["photodamage score — From enrollment to the end of treatment at 16 weeks","Melanin Index — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","Erythema Index — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","Transepidermal Water Loss — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","skin hydration — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","dermal thickness — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16.","elasticity index — Assessments were conducted at at weeks 0 (baseline), 4, 8, 12, and 16."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: photoaging.","Abstract contains controlled term: photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39467","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}