{"type":"trials","record":{"id":39495,"source_id":"clinicaltrials-gov","external_id":"NCT06603857","title":"Skin Care Regimen for Improving Photoaging Signs on the Face","brief_summary":"Compare the effectiveness of laser treatment using CE Ferulic versus vehicle pre/post laser.","overall_status":"Not Yet Recruiting","phases":["PHASE2","PHASE3"],"study_type":"INTERVENTIONAL","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","enrollment":40,"countries":["United States"],"start_date":"2024-09-27","completion_date":"2025-02-28","last_update_date":"2024-09-19","source_url":"https://clinicaltrials.gov/study/NCT06603857","editorial_summary":"A registered PHASE2, PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"30 Years to 70 Years","comparator":"Group A","organization":"Goldman, Butterwick, Fitzpatrick and Groff","interventions":["CE Ferulic","Sham Comparator","1927nm (Clear and Brilliant Perméa®)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Global Fine Lines — Screening, Baseline, Day 28, Day 56, Day 84","Overall Hyperpigmentation/ Discoloration — Screening, Baseline, Day 28, Day 56, Day 84","Skin Tone Evenness — Screening, Baseline, Day 28, Day 56, Day 84","Skin Elasticity — Screening, Baseline, Day 28, Day 56, Day 84","Skin Firmness — Screening, Baseline, Day 28, Day 56, Day 84","Skin Radiance/ Brightness — Screening, Baseline, Day 28, Day 56, Day 84","Skin Texture Smoothness — Screening, Baseline, Day 28, Day 56, Day 84","Global Wrinkles — Screening, Baseline, Day 28, Day 56, Day 84","Tolerability Assessment — Baseline, Day 28","Dermatology Quality of Life Index (Page 1) — Screening, Baseline, Day 28, Day 56, Day 84","Dermatology Quality of Life Index (Page 2) — Screening, Baseline, Day 28, Day 56, Day 84","Subject Self-Assessment Questionnaire (Page 1) — Screening, Baseline, Day 28, Day 56, Day 84","Subject Self-Assessment Questionnaire (Page 2) — Screening, Baseline, Day 28, Day 56, Day 84","Subject Self-Assessment Questionnaire (Page 3) — Screening, Baseline, Day 28, Day 56, Day 84"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","source_has_results":false},"controlled_terms":["Improve Photoaging Signs","CE Ferulic","Sham Comparator","1927nm (Clear and Brilliant Perméa®)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: photoaging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct06603857","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-27 to 2025-02-28","comparator":"Group A","confidence":"structured-source","population":"ALL · 30 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.580Z","intervention":["CE Ferulic","Sham Comparator","1927nm (Clear and Brilliant Perméa®)"],"participants":40,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2, PHASE3","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Global Fine Lines — Screening, Baseline, Day 28, Day 56, Day 84","Overall Hyperpigmentation/ Discoloration — Screening, Baseline, Day 28, Day 56, Day 84","Skin Tone Evenness — Screening, Baseline, Day 28, Day 56, Day 84","Skin Elasticity — Screening, Baseline, Day 28, Day 56, Day 84","Skin Firmness — Screening, Baseline, Day 28, Day 56, Day 84","Skin Radiance/ Brightness — Screening, Baseline, Day 28, Day 56, Day 84","Skin Texture Smoothness — Screening, Baseline, Day 28, Day 56, Day 84","Global Wrinkles — Screening, Baseline, Day 28, Day 56, Day 84","Tolerability Assessment — Baseline, Day 28","Dermatology Quality of Life Index (Page 1) — Screening, Baseline, Day 28, Day 56, Day 84","Dermatology Quality of Life Index (Page 2) — Screening, Baseline, Day 28, Day 56, Day 84","Subject Self-Assessment Questionnaire (Page 1) — Screening, Baseline, Day 28, Day 56, Day 84","Subject Self-Assessment Questionnaire (Page 2) — Screening, Baseline, Day 28, Day 56, Day 84","Subject Self-Assessment Questionnaire (Page 3) — Screening, Baseline, Day 28, Day 56, Day 84"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: photoaging.","Source terminology contains: photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39495","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}