{"type":"trials","record":{"id":39520,"source_id":"clinicaltrials-gov","external_id":"NCT06125912","title":"A Comparative Split-Face Study of the Effects of a Retinol Alternative Cream on Improving Facial Skin Aging","brief_summary":"This study will evaluate the efficacy of the DIME TBT Cream in improving the appearance and hydration of aged skin in comparison to a retinol cream. This study will last for 60 days. The study will be conducted as a single-arm trial in which all participants will use both the test product and the positive control product (0.1% Retinol Clinical Trial Lotion). Participants will be required to undertake questionnaires at Baseline, Day 30, and Day 60. Photos will be taken at Baseline, Day 30, and Day 60, and expert skin grading will take place at Baseline and Day 60.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Dime Beauty Co.","enrollment":35,"countries":["United States"],"start_date":"2023-09-25","completion_date":"2024-02-15","last_update_date":"2024-02-22","source_url":"https://clinicaltrials.gov/study/NCT06125912","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"18 Years to 65 Years","comparator":null,"organization":"Dime Beauty Co.","interventions":["Dime Beauty TBT Cream","Positive Control"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in the appearance of fine lines and wrinkles on the face. [Baseline to Day 60] — 60 days","Change in participants' perception of the appearance of fine lines and wrinkles on the face. [Baseline to Day 60] — 60…","Change in skin elasticity. [Baseline to Day 60] — 60 days","Changes in signs of skin aging. [Baseline to Day 60] — 60 days","Changes in participants' perception of signs of skin aging. [Baseline to Day 60] — 60 days","Changes in participants' perception of facial skin hydration. [Baseline to Day 60] — 60 days","Changes in facial skin hydration. [Baseline to Day 60] — 60 days","Comparison of the visual changes in the signs of skin aging as a result of using the test product compared to the contr…","Comparison of participants perception of the visual changes in the signs of skin aging as a result of using the test pr…"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":false},"controlled_terms":["Skin Aging","Dime Beauty TBT Cream","Positive Control"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct06125912","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-09-25 to 2024-02-15","comparator":null,"confidence":"structured-source","population":"FEMALE · 18 Years to 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.584Z","intervention":["Dime Beauty TBT Cream","Positive Control"],"participants":35,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in the appearance of fine lines and wrinkles on the face. [Baseline to Day 60] — 60 days","Change in participants' perception of the appearance of fine lines and wrinkles on the face. [Baseline to Day 60] — 60…","Change in skin elasticity. [Baseline to Day 60] — 60 days","Changes in signs of skin aging. [Baseline to Day 60] — 60 days","Changes in participants' perception of signs of skin aging. [Baseline to Day 60] — 60 days","Changes in participants' perception of facial skin hydration. [Baseline to Day 60] — 60 days","Changes in facial skin hydration. [Baseline to Day 60] — 60 days","Comparison of the visual changes in the signs of skin aging as a result of using the test product compared to the contr…","Comparison of participants perception of the visual changes in the signs of skin aging as a result of using the test pr…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Source terminology contains: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39520","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}