{"type":"trials","record":{"id":39523,"source_id":"clinicaltrials-gov","external_id":"NCT06217627","title":"Skin Rejuvenation Using Stem Cell Secretome","brief_summary":"This clinical trial aims to investigate the effect of umbilical cord explants (UC)-explants and UC-mesenchymal stem cells (MSCs) secretome on skin rejuvenation, to provide future reference or standard in the application of cell free-based therapy in skin aging.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"COR clinic of Regenerative Medicine","enrollment":49,"countries":["Lebanon"],"start_date":"2021-03-05","completion_date":"2023-06-30","last_update_date":"2024-02-06","source_url":"https://clinicaltrials.gov/study/NCT06217627","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:30:28.369+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"25 Years","comparator":null,"organization":"COR clinic of Regenerative Medicine","interventions":["secretome"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Selected growth factors assessment — 4 samples of secretome extracted from UC-explants with one week interval. 1 sample…","Wrinkle severity in hands — digital photographs before injection and after 7 months.","Wrinkle severity in the face and neck — digital photographs before injection and after 7 months.","Histological examination — skin biopsies were performed at two moments: before treatment and after 12 months."],"design_description":"RANDOMIZED · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Skin Rejuvenation","secretome"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-25T06:30:29.928011+00:00","duplicate_cluster_key":"id:nct06217627","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-03-05 to 2023-06-30","comparator":null,"confidence":"structured-source","population":"FEMALE · 25 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:30:28.386Z","intervention":["secretome"],"participants":49,"study_design":"RANDOMIZED · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Selected growth factors assessment — 4 samples of secretome extracted from UC-explants with one week interval. 1 sample…","Wrinkle severity in hands — digital photographs before injection and after 7 months.","Wrinkle severity in the face and neck — digital photographs before injection and after 7 months.","Histological examination — skin biopsies were performed at two moments: before treatment and after 12 months."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Abstract contains controlled term: stem cell.","Title supplies longevity context: rejuvenation.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39523","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}