{"type":"trials","record":{"id":39525,"source_id":"clinicaltrials-gov","external_id":"NCT05854628","title":"The Role of Red Flavonoid in Photoaging","brief_summary":"The goal of this clinical trial is to learn about the effects of \"red flavonoid\" substance on skin, which is extracted from a plant called Camellia japonica, in adults aged of 45 or older with photo-damaged skin. The main questions it aims to answer are: * Does red flavonoid have an anti-aging effect? * Does red flavonoid have any skin quality-improving effects? Participants will * Be using creams with or without red flavonoid (only moisturizing creams) and sun-screen for the duration of the study. * Get a skin biopsy before and after using the creams. * Be taken photos of the face and neck region and have a skin examination at each visit. * Complete a self-questionnaire at final visit. Researchers will compare the group who uses red flavonoid facial cream with the group who uses moisturizing cream to see if red flavonoid has an effect on appearance and structure.","overall_status":"Withdrawn","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Johns Hopkins University","enrollment":0,"countries":[],"start_date":"2023-10-01","completion_date":"2025-05-01","last_update_date":"2023-12-19","source_url":"https://clinicaltrials.gov/study/NCT05854628","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"45 Years","comparator":"Placebo facial cream","organization":"Johns Hopkins University","interventions":["skin biopsy"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Fibrillin-1 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 weeks,…","Collagen type-4 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 wee…","Collagen type-1 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 wee…","Tyrosinase fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 weeks, 2…","Wrinkles/photoaging as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks","Hydration as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks","Loss of elasticity as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks","Brightness as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE","source_has_results":false},"controlled_terms":["Photoaging of Skin","Skin Aging","skin biopsy"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: photoaging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct05854628","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-10-01 to 2025-05-01","comparator":"Placebo facial cream","confidence":"structured-source","population":"ALL · 45 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.584Z","intervention":["skin biopsy"],"participants":0,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Fibrillin-1 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 weeks,…","Collagen type-4 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 wee…","Collagen type-1 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 wee…","Tyrosinase fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — 8 weeks, 16 weeks, 2…","Wrinkles/photoaging as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks","Hydration as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks","Loss of elasticity as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks","Brightness as assessed by clinical assessments — 8 weeks, 16 weeks, 24 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: photoaging.","Source terminology contains: skin aging, photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39525","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}