{"type":"trials","record":{"id":39537,"source_id":"clinicaltrials-gov","external_id":"NCT06083402","title":"Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women","brief_summary":"As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity. In this double-blind, randomized, placebo-controlled trial, the investigators will recruit healthy men and women with mild to moderate signs of skin aging and randomly assign them to either receive a HyaCera™ or placebo for 12 weeks. The investigators will perform a series of objective and subjective measurements to assess changes in skin condition. The investigators hypothesize that consumption of HyaCera™ leads to improvements in the general condition of the skin including skin hydration, crow's feet wrinkling, and other skin aging parameters.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Natals, Inc. dba Ritual","enrollment":63,"countries":["United States"],"start_date":"2023-06-12","completion_date":"2023-10-06","last_update_date":"2023-10-16","source_url":"https://clinicaltrials.gov/study/NCT06083402","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"25 Years to 70 Years","comparator":"Active; Placebo","organization":"Natals, Inc. dba Ritual","interventions":["HyaCera™","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Crow's Feet Wrinkles — at week 0, Week 4, Week 8, and Week 12","Skin Smoothness — at week 0, Week 4, Week 8, and Week 12","Skin Hydration — at week 0, Week 4, Week 8, and Week 12","Skin Elasticity — at week 0, Week 4, Week 8, and Week 12","Skin Barrier Function — at week 0, Week 4, Week 8, and Week 12","Skin Scaliness — at week 0, Week 4, Week 8, and Week 12"],"design_description":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","source_has_results":false},"controlled_terms":["Skin Aging","HyaCera™","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct06083402","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-06-12 to 2023-10-06","comparator":"Active; Placebo","confidence":"structured-source","population":"ALL · 25 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.586Z","intervention":["HyaCera™","Placebo"],"participants":63,"study_design":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Crow's Feet Wrinkles — at week 0, Week 4, Week 8, and Week 12","Skin Smoothness — at week 0, Week 4, Week 8, and Week 12","Skin Hydration — at week 0, Week 4, Week 8, and Week 12","Skin Elasticity — at week 0, Week 4, Week 8, and Week 12","Skin Barrier Function — at week 0, Week 4, Week 8, and Week 12","Skin Scaliness — at week 0, Week 4, Week 8, and Week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging.","Source terminology contains: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39537","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}