{"type":"trials","record":{"id":39577,"source_id":"clinicaltrials-gov","external_id":"NCT05096650","title":"Platelet Rich Plasma for Treatment of Facial Photoaging: A Double-blind, Randomized, Split-face Study","brief_summary":"Photoaging is characterized by cellular changes and alterations in dermal extracellular matrix proteins with degeneration of connective tissue caused by intrinsic and extrinsic factors. The clinical manifestations of photoaging included wrinkles, pigmented changes, tissue loss, and sagging. Autologous platelet-rich plasma is a preparation of platelets in concentrated plasma from peripheral blood. The α granules of platelets contained many growth factors. According to previous literature, growth factors in platelet-rich plasma directly stimulate fibroblast proliferation to boost collagen production. It has also been shown to modulate extracellular matrix metabolism and remodeling by increasing the expression of specific matrix metalloproteinases. In review of previous literatures, there was only limited researches of platelet-rich plasma for treatment of photoaging. Therefore, the present study was conducted for analyzing the efficacy and safety of autologous platelet-rich plasma in photoaging therapy.","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Chang Gung Memorial Hospital","enrollment":15,"countries":["Taiwan"],"start_date":"2021-11-30","completion_date":"2022-08-31","last_update_date":"2021-10-27","source_url":"https://clinicaltrials.gov/study/NCT05096650","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"20 Years","comparator":null,"organization":"Chang Gung Memorial Hospital","interventions":["mesotherapy of platelet rich plasma and platelet poor plasma"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Global Aesthetic Improvement Scale — 3 months after the last session of treatment","Fitzpatrick wrinkle scale — 3 months after the last session of treatment","Wrinkle Severity Rating scale — 3 months after the last session of treatment","The scores of rhytids in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 months aft…","The scores of texture in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 months aft…","The scores of pores size in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 months…","The scores of pigment spots in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 mont…","The scores of brownish spots in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 mon…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":false},"controlled_terms":["Platelet-Rich Plasma","Aging","mesotherapy of platelet rich plasma and platelet poor plasma"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: photoaging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct05096650","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-11-30 to 2022-08-31","comparator":null,"confidence":"structured-source","population":"ALL · 20 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.592Z","intervention":["mesotherapy of platelet rich plasma and platelet poor plasma"],"participants":15,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Global Aesthetic Improvement Scale — 3 months after the last session of treatment","Fitzpatrick wrinkle scale — 3 months after the last session of treatment","Wrinkle Severity Rating scale — 3 months after the last session of treatment","The scores of rhytids in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 months aft…","The scores of texture in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 months aft…","The scores of pores size in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 months…","The scores of pigment spots in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 mont…","The scores of brownish spots in VISIA system — before the 1st, 2nd and 3rd sessions of treatment as well as 1 and 3 mon…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: photoaging.","Abstract contains controlled term: photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39577","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}