{"type":"trials","record":{"id":39594,"source_id":"clinicaltrials-gov","external_id":"NCT04586816","title":"Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging","brief_summary":"Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles. Red maple leaf extract contains phenolic compounds known as glucitol-core-containing gallotannins (GCGs) which help reduce the appearance of wrinkles and may decrease skin inflammation, dark spots and pigmentation. The objective of this study is to examine the effects of topical Maplifa on the cosmetic appearance of facial lines, redness and skin tone.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Integrative Skin Science and Research","enrollment":19,"countries":["United States"],"start_date":"2019-09-10","completion_date":"2020-01-15","last_update_date":"2020-10-14","source_url":"https://clinicaltrials.gov/study/NCT04586816","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"30 Years to 70 Years","comparator":"vehicle only-placebo","organization":"Integrative Skin Science and Research","interventions":["1% red maple leaf extract in cream base","5% red maple leaf extract","vehicle"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Pigmentation on SkinColorCatch — At 4 weeks (end of study)","Clinical grading of Hyperpigmentation — At 4 weeks (end of study)","Erythema on SkinColorCatch — At 4 weeks (end of study)","Clinical grading of Erythema — At 4 weeks (end of study)","Centrofacial redness — At 4 weeks (end of study)","Appearance of wrinkles — At 4 weeks (end of study)"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Photoaging","Hyperpigmentation","Rhytides","1% red maple leaf extract in cream base","5% red maple leaf extract","vehicle"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: photoaging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct04586816","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-09-10 to 2020-01-15","comparator":"vehicle only-placebo","confidence":"structured-source","population":"FEMALE · 30 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.594Z","intervention":["1% red maple leaf extract in cream base","5% red maple leaf extract","vehicle"],"participants":19,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Pigmentation on SkinColorCatch — At 4 weeks (end of study)","Clinical grading of Hyperpigmentation — At 4 weeks (end of study)","Erythema on SkinColorCatch — At 4 weeks (end of study)","Clinical grading of Erythema — At 4 weeks (end of study)","Centrofacial redness — At 4 weeks (end of study)","Appearance of wrinkles — At 4 weeks (end of study)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: photoaging.","Source terminology contains: photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39594","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}