{"type":"trials","record":{"id":39598,"source_id":"clinicaltrials-gov","external_id":"NCT04123743","title":"Efficacy of Extract of Trigonella Foenum-graceum as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women","brief_summary":"Skin is subjected to intrinsic aging and extrinsic aging. Intrinsic aging is influenced by genetic and hormonal factors. Estrogen has significant role in modulating skin physiology. In post menopausal women, skin aging is accelerated because of hypoestrogenism. Administration of estrogen can delay the process of skin aging. Phytoestrogens are estrogen-like compounds which can be found naturally in plants. The investigators intend to study the efficacy of Trigonella foenum-graceum extract as topical phytoestrogen in skin aging treatment of post menopausal women.","overall_status":"Completed","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Universitas Indonesia","enrollment":21,"countries":["Indonesia"],"start_date":"2019-08-10","completion_date":"2019-11-10","last_update_date":"2020-07-29","source_url":"https://clinicaltrials.gov/study/NCT04123743","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":null,"comparator":"Control Group","organization":"Universitas Indonesia","interventions":["Trigonella foenum-graceum extract topical cream","Facial Wash","Sunscreen Cream","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Visual Analogue Scale for Forehead Wrinkles — Change from initial visit VAS at 12 weeks","Visual Analogue Scale for Crow's Feet Wrinkles — Change from initial visit VAS at 12 weeks","Visual Analogue Scale for Nasolabial Wrinkles — Change from initial visit VAS at 12 weeks","High Resolution Ultrasound — Change from initial visit dermis thickness at 12 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Skin Aging","Trigonella foenum-graceum extract topical cream","Facial Wash","Sunscreen Cream","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct04123743","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-08-10 to 2019-11-10","comparator":"Control Group","confidence":"structured-source","population":"FEMALE","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.595Z","intervention":["Trigonella foenum-graceum extract topical cream","Facial Wash","Sunscreen Cream","Placebo"],"participants":21,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Visual Analogue Scale for Forehead Wrinkles — Change from initial visit VAS at 12 weeks","Visual Analogue Scale for Crow's Feet Wrinkles — Change from initial visit VAS at 12 weeks","Visual Analogue Scale for Nasolabial Wrinkles — Change from initial visit VAS at 12 weeks","High Resolution Ultrasound — Change from initial visit dermis thickness at 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging.","Source terminology contains: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39598","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}