{"type":"trials","record":{"id":39616,"source_id":"clinicaltrials-gov","external_id":"NCT03460860","title":"Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Treatment Of Skin Aging","brief_summary":"The purpose of this study is to determine the clinical efficacy of a combination of Astaxanthin (2 mg), Lycopene (1.8 mg), and d-alpha-Tocopherol (10 IU) in terms of its skin anti-aging properties. Specifically, the investigators aim to determine the increase in hydration levels of the skin, decrease in atypical skin pigmentation, and reduction of signs of photoaging, particularly facial fine lines.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"United Laboratories","enrollment":100,"countries":["Philippines"],"start_date":"2018-03-05","completion_date":"2019-02-07","last_update_date":"2019-06-26","source_url":"https://clinicaltrials.gov/study/NCT03460860","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"30 Years to 60 Years","comparator":"Placebo","organization":"United Laboratories","interventions":["Astaxanthin (2mg)+Lycopene (1.8mg)+D-Alpha-Tocopherol (10IU)","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Proportion of subjects within each treatment group with a significant decrease in skin wrinkling measured by a validate…","Proportion of subjects within each treatment group with a significant increase in skin hydration measured by a corneome…","Proportion of subjects within each treatment group with a significant decrease in pigmentation measured by a mexameter.…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Skin Aging","Wrinkles","Astaxanthin (2mg)+Lycopene (1.8mg)+D-Alpha-Tocopherol (10IU)","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct03460860","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-03-05 to 2019-02-07","comparator":"Placebo","confidence":"structured-source","population":"ALL · 30 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.598Z","intervention":["Astaxanthin (2mg)+Lycopene (1.8mg)+D-Alpha-Tocopherol (10IU)","Placebo"],"participants":100,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Proportion of subjects within each treatment group with a significant decrease in skin wrinkling measured by a validate…","Proportion of subjects within each treatment group with a significant increase in skin hydration measured by a corneome…","Proportion of subjects within each treatment group with a significant decrease in pigmentation measured by a mexameter.…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: photoaging.","Source terminology contains: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39616","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}