{"type":"trials","record":{"id":39617,"source_id":"clinicaltrials-gov","external_id":"NCT00520910","title":"Efficacy of Polypodium Leucotomos Extract Decreasing UVA Premutagenic and Photoaging Markers","brief_summary":"With this study, the investigators will like to determine if taking a dose of the study medication, called Polypodium leucotomos (PL), prevents some of the changes in the skin caused by the adverse effects of UVA, a type of ultraviolet light.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"University of Miami","enrollment":10,"countries":["United States"],"start_date":"2007-08-01","completion_date":"2009-05-01","last_update_date":"2019-06-18","source_url":"https://clinicaltrials.gov/study/NCT00520910","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":"No intervention","organization":"University of Miami","interventions":["Polypodium leucotomos"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Common Deletion (CD) Value in DNA of Skin Biopsy Sample — baseline, 24 hours","8-oxo-7,8-dihydro-2'-Deoxyguanosine (8-oxo-dG) Quantification in Skin Biopsy Sample Taken From Final Visit — 24 hours"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","source_has_results":true},"controlled_terms":["Aging","Skin Abnormalities","Polypodium leucotomos"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: photoaging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct00520910","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2007-08-01 to 2009-05-01","comparator":"No intervention","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.598Z","intervention":["Polypodium leucotomos"],"participants":10,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Common Deletion (CD) Value in DNA of Skin Biopsy Sample — baseline, 24 hours","8-oxo-7,8-dihydro-2'-Deoxyguanosine (8-oxo-dG) Quantification in Skin Biopsy Sample Taken From Final Visit — 24 hours"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39617","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}