{"type":"trials","record":{"id":39629,"source_id":"clinicaltrials-gov","external_id":"NCT00701740","title":"Oral Isotretinoin for Photoaging: Results of a Randomized Controlled Phase II Trial","brief_summary":"A clinical and histological randomized controlled phase II trial to evaluate the efficacy and safety of oral isotretinoin for treating photoaging was performed with 32 menopausal or sterilized women aged 40-55y. The subjects were included in two randomly selected groups: A- 21 women received 20mg oral isotretinoin 3x week, moisturizer, sunscreen SPF 60 during three months; B- 11 women received only same moisturizer/sunscreen.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Federal University of São Paulo","enrollment":32,"countries":["Brazil"],"start_date":"2007-07-01","completion_date":"2008-06-01","last_update_date":"2018-08-15","source_url":"https://clinicaltrials.gov/study/NCT00701740","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"40 Years to 55 Years","comparator":"A; B","organization":"Federal University of São Paulo","interventions":["oral isotretinoin and Mexoryl SX / XL","Mexoryl XL / SX"],"registry_source":"ClinicalTrials.gov","outcome_measures":["histological findings — before and after 3 months","laboratory tests — before, after 1 and 3 months"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Photoaging","Epidermal p53 Expression","oral isotretinoin and Mexoryl SX / XL","Mexoryl XL / SX"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: photoaging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct00701740","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2007-07-01 to 2008-06-01","comparator":"A; B","confidence":"structured-source","population":"FEMALE · 40 Years to 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.600Z","intervention":["oral isotretinoin and Mexoryl SX / XL","Mexoryl XL / SX"],"participants":32,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["histological findings — before and after 3 months","laboratory tests — before, after 1 and 3 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: photoaging.","Abstract contains controlled term: photoaging.","Source terminology contains: photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39629","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}