{"type":"trials","record":{"id":39647,"source_id":"clinicaltrials-gov","external_id":"NCT02373111","title":"Effects of Isoflavone Combined With Astaxanthin on Skin Aging","brief_summary":"Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined. Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals. In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively. The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Seoul National University Hospital","enrollment":90,"countries":["South Korea"],"start_date":"2015-03-01","completion_date":"2015-12-01","last_update_date":"2016-06-14","source_url":"https://clinicaltrials.gov/study/NCT02373111","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"45 Years","comparator":"Isoflavone and Astaxanthin; Placebo","organization":"Seoul National University Hospital","interventions":["Isoflavone","Astaxanthin","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from baseline in skin wrinkles — Twenty-four weeks","Change from baseline in skin elasticity — Twenty-four weeks","Change from baseline in epidermal hydration — Twenty-four weeks","Change from baseline in skin barrier integrity — Tewnty-four weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Ageing","Photo-aging","Isoflavone","Astaxanthin","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct02373111","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-03-01 to 2015-12-01","comparator":"Isoflavone and Astaxanthin; Placebo","confidence":"structured-source","population":"FEMALE · 45 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.602Z","intervention":["Isoflavone","Astaxanthin","Placebo"],"participants":90,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from baseline in skin wrinkles — Twenty-four weeks","Change from baseline in skin elasticity — Twenty-four weeks","Change from baseline in epidermal hydration — Twenty-four weeks","Change from baseline in skin barrier integrity — Tewnty-four weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging, photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39647","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}