{"type":"trials","record":{"id":39648,"source_id":"clinicaltrials-gov","external_id":"NCT02060097","title":"Effects of Cocoa Flavanol on Skin Aging","brief_summary":"Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) likely contribute to this process. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined. Cocoa beans fresh from the tree are exceptionally rich in polyphenols, such as flavanol, and have a higher antioxidant capacity. The present study is designed to investigate the effects of long-term intake of a product rich in cocoa flavanols on facial wrinkles, hydration, elasticity and photosensitivity.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Seoul National University Hospital","enrollment":64,"countries":["South Korea"],"start_date":"2014-02-01","completion_date":"2015-03-01","last_update_date":"2016-06-14","source_url":"https://clinicaltrials.gov/study/NCT02060097","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:19.060264+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"40 Years","comparator":"Cocoa flavanol beverage; Placebo beverage","organization":"Seoul National University Hospital","interventions":["Cocoa flavanol beverage","Placebo beverage"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from baseline in skin wrinkles at week 24 — baseline, week 24","Change from baseline in skin elasticity at week 24 — baseline, week 24","Change from baseline in minimal erythema dose at week 24 — baseline, week 24","Change from baseline in skin hydration at week 12 — baseline, week 12","Change from baseline in skin color at week 12 — baseline, week 12"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Ageing","Photo-aging","Cocoa flavanol beverage","Placebo beverage"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct02060097","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-02-01 to 2015-03-01","comparator":"Cocoa flavanol beverage; Placebo beverage","confidence":"structured-source","population":"FEMALE · 40 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.603Z","intervention":["Cocoa flavanol beverage","Placebo beverage"],"participants":64,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from baseline in skin wrinkles at week 24 — baseline, week 24","Change from baseline in skin elasticity at week 24 — baseline, week 24","Change from baseline in minimal erythema dose at week 24 — baseline, week 24","Change from baseline in skin hydration at week 12 — baseline, week 12","Change from baseline in skin color at week 12 — baseline, week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: photoaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/39648","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}