{"type":"trials","record":{"id":40,"source_id":"clinicaltrials-gov","external_id":"NCT03353597","title":"Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects","brief_summary":"This trial is designed to study the effects of monthly transfusions of young healthy male donor plasma on biological age as assessed by DNA methylation levels, and changes in cognitive, renal, and pulmonary function, muscle strength, telomere length, testosterone, estrogen, DHEAS, IGF-1, high resolution C-Reactive protein, and expression of P16INK4a in peripheral blood T lymphocytes and skin biopsies.","overall_status":"Unknown","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Chandra Duggirala","enrollment":2120,"countries":["United States"],"start_date":"2018-05-15","completion_date":"2022-12-15","last_update_date":"2018-01-17","source_url":"https://clinicaltrials.gov/study/NCT03353597","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:58.543517+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":"RESET-YOUTH","age_range":"40 Years","comparator":null,"organization":"Fountain Labs, Inc.","interventions":["Plasma Transfusion"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Biological age as assessed by DNA methylation levels, to calculate the Epigenetic age. — Baseline to end of Month 9.","Mental (Cognitive) Function — Baseline and Month 9","Lung (Pulmonary) Function — Baseline and Month 9","Kidney (Renal) Function — Baseline and Month 9","Muscle Strength — Baseline and Month 9","Telomere Length — Baseline and Month 9","Testosterone — Baseline and Month 9","Estrogen — Baseline and Month 9","DHEAS — Baseline and Month 9","IGF-1 — Baseline and Month 9","High Sensitivity C-Reactive Protein — Baseline and Month 9","P16INK4a (A marker of cellular aging) — Baseline and Month 9"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Aging","Plasma Transfusion"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: young plasma.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct03353597","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-05-15 to 2022-12-15","comparator":null,"confidence":"structured-source","population":"ALL · 40 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:14.010Z","intervention":["Plasma Transfusion"],"participants":2120,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Biological age as assessed by DNA methylation levels, to calculate the Epigenetic age. — Baseline to end of Month 9.","Mental (Cognitive) Function — Baseline and Month 9","Lung (Pulmonary) Function — Baseline and Month 9","Kidney (Renal) Function — Baseline and Month 9","Muscle Strength — Baseline and Month 9","Telomere Length — Baseline and Month 9","Testosterone — Baseline and Month 9","Estrogen — Baseline and Month 9","DHEAS — Baseline and Month 9","IGF-1 — Baseline and Month 9","High Sensitivity C-Reactive Protein — Baseline and Month 9","P16INK4a (A marker of cellular aging) — Baseline and Month 9"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"young-blood-parabiosis","is_published":true,"match_reasons":["Title contains controlled term: young plasma.","Title supplies longevity context: senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Young blood and parabiosis","slug":"young-blood-parabiosis"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/40","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}