{"type":"trials","record":{"id":40029,"source_id":"clinicaltrials-gov","external_id":"NCT04281264","title":"Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly","brief_summary":"Due to age-related effects, the bone and cardiovascular health are damaged. Physical exercise and in particular the strength training has been proposed as a fundamental tool to these pathologies, especially in the elderly. On the other hand, the use of normobaric hypoxia combined with exercise could have a beneficial synergistic effect on disease prevention and the quality of life of the elderly. Therefore, the general objective of this project is to analyze the effects of different methods of strength training combined with conditions of normobaric hypoxia on the bone and cardiovascular health of the elderly. This general objective is specified in the following specific objectives: * To analyze the effects of circuit training with elastic bands on bone mineral density and bone remodelling markers of elderly, under normoxic and normobaric hypoxic conditions. * To analyze the effects of circuit training with elastic bands on biochemical parameters, inflammatory, endothelial and clinical markers just like cardiovascular risk level of elderly, under normoxic and normobaric hypoxic conditions. * To analyze the effects of circuit training with elastic bands on body composition and functional capacity of elderly, under normoxic and normobaric hypoxic conditions. * To analyze the effects of whole-body vibration training on bone mineral density and bone remodelling markers of elderly, under normoxic and normobaric hypoxic conditions. * To analyze the effects of whole-body vibration training on biochemical parameters, inflammatory, endothelial and clinical markers just like cardiovascular risk level of elderly, under normoxic and normobaric hypoxic conditions. * To analyze the effects of whole-body vibration training on body composition and functional capacity of elderly, under normoxic and normobaric hypoxic conditions. * To compare the effects of circuit training with elastic bands versus whole-body vibration training on bone and cardiovascular health of elderly, under normoxic and normobaric hypoxic conditions. * To value the normobaric hypoxic environment efficacy on bone and cardiovascular health of elderly subjected to circuit training with elastic bands and whole-body vibration training. We hypothesize that bone and cardiovascular health will improve in the participants subjected to both resistance training, but greater improved may be found when these protocol are combined with normobaric hypoxia.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Extremadura","enrollment":120,"countries":["Spain"],"start_date":"2019-02-09","completion_date":"2021-06-30","last_update_date":"2021-07-07","source_url":"https://clinicaltrials.gov/study/NCT04281264","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:22.160691+00:00","last_seen_at":"2026-09-25T06:20:19.667+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 80 Years","comparator":"NorCON; HypCON; NorCIR; NorVIB","organization":"University of Extremadura","interventions":["Passive Hypoxia","Normoxia Circuit Training with Elastic Bands","Hypoxia Circuit Training with Elastic Bands","Normoxia Vibration","Hypoxia Vibration"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from Baseline Life Quality at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Risk of Fall at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Blood Pressure at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Cardiovascular Evaluation at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Cardiovascular Risk at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Weight at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Height at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Body Mass Index at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Waist-Hip Ratio at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Body Composition at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Bone Mineral Density at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Osteoporosis/Osteopenia Prevalence at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Bone Mineral Content at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Biochemical Parameters at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Bone Remodelling Markers at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Inflammatory Markers at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Endothelial Markers at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Lower Limb Strength at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Upper Limb Strength at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Lower Limb Flexibility at 24 weeks — Through study completion, an average of 24 weeks"],"design_description":"RANDOMIZED · FACTORIAL · SUPPORTIVE CARE · DOUBLE","source_has_results":false},"controlled_terms":["Aging Well","Passive Hypoxia","Normoxia Circuit Training with Elastic Bands","Hypoxia Circuit Training with Elastic Bands","Normoxia Vibration","Hypoxia Vibration"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T06:20:27.00315+00:00","duplicate_cluster_key":"id:nct04281264","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-02-09 to 2021-06-30","comparator":"NorCON; HypCON; NorCIR; NorVIB","confidence":"structured-source","population":"ALL · 65 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:19.736Z","intervention":["Passive Hypoxia","Normoxia Circuit Training with Elastic Bands","Hypoxia Circuit Training with Elastic Bands","Normoxia Vibration","Hypoxia Vibration"],"participants":120,"study_design":"RANDOMIZED · FACTORIAL · SUPPORTIVE CARE · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from Baseline Life Quality at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Risk of Fall at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Blood Pressure at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Cardiovascular Evaluation at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Cardiovascular Risk at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Weight at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Height at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Body Mass Index at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Waist-Hip Ratio at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Body Composition at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Bone Mineral Density at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Osteoporosis/Osteopenia Prevalence at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Bone Mineral Content at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Biochemical Parameters at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Bone Remodelling Markers at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Inflammatory Markers at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Endothelial Markers at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Lower Limb Strength at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Upper Limb Strength at 24 weeks — Through study completion, an average of 24 weeks","Change from Baseline Lower Limb Flexibility at 24 weeks — Through study completion, an average of 24 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: resistance training, strength training.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/40029","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}