{"type":"trials","record":{"id":40207,"source_id":"clinicaltrials-gov","external_id":"NCT00558012","title":"Zoledronic Acid for Osteoporosis in the Elderly","brief_summary":"This trial will examine the safety, efficacy and feasibility of a single dose of intravenous zoledronic acid in the maintenance of skeletal integrity for frail, institutionalized women, who are most at risk for the deleterious outcomes of osteoporosis. The investigators will test the hypothesis that in institutionalized elderly women a single dose of intravenous zoledronic acid therapy will: (1) be efficacious as demonstrated by stability or improvement in bone mass measurements and reductions in bone turnover; (2) be safe and feasible; and (3) provide estimates for vertebral and nonvertebral fracture reduction in this cohort for use in planning a future study.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Pittsburgh","enrollment":181,"countries":["United States"],"start_date":"2007-12-01","completion_date":"2014-02-01","last_update_date":"2015-07-31","source_url":"https://clinicaltrials.gov/study/NCT00558012","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:22.160691+00:00","last_seen_at":"2026-09-25T06:20:19.667+00:00","metadata":{"sex":"FEMALE","acronym":"ZEST","age_range":"65 Years","comparator":"Placebo","organization":"University of Pittsburgh","interventions":["Intravenous zoledronic acid","Vitamin D 800 IU/daily","Calcium 1200 mg/daily"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Bone Mineral Density (BMD) of the Total Hip and Spine — Baseline, 12 months, 24 month"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":true},"controlled_terms":["Osteoporosis","Bone Loss","Fragility Fractures","Intravenous zoledronic acid","Vitamin D 800 IU/daily","Calcium 1200 mg/daily"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: osteoporosis.","quality_checked_at":"2026-09-25T06:20:27.00315+00:00","duplicate_cluster_key":"id:nct00558012","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2007-12-01 to 2014-02-01","comparator":"Placebo","confidence":"structured-source","population":"FEMALE · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:19.768Z","intervention":["Intravenous zoledronic acid","Vitamin D 800 IU/daily","Calcium 1200 mg/daily"],"participants":181,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Bone Mineral Density (BMD) of the Total Hip and Spine — Baseline, 12 months, 24 month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"bone-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoporosis.","Abstract contains controlled term: osteoporosis.","Source terminology contains: osteoporosis.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Bone ageing","slug":"bone-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/40207","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}