{"type":"trials","record":{"id":40211,"source_id":"clinicaltrials-gov","external_id":"NCT00718432","title":"An Interventional Study of Geriatric Frailty, Osteoporosis, and Depression","brief_summary":"Frailty, osteoporosis, and depression are three highly prevalent geriatric syndromes. Having these conditions are associated with adverse outcome in physical health, mental health, quality of life, and daily functioning. They are associated with higher mortality rates as well as increased health care cost. Risk factors, pathogenesis, clinical phenotypes, and interventions of these three geriatric syndromes are often related. Frailty is often defined as accumulations of multi-system deficiencies with increased vulnerability to multiple worse outcomes. Multifactorial, interdisciplinary integrated care models targeting frail older adults may have positive impacts on measurements associated with not only frailty, but also depression, or osteoporosis. The objective of this proposed study is to conduct a randomized control trial (RCT) to exam the effectiveness of integrated interventions on multiple outcomes among community-dwelling Taiwanese elders with high risks for frailty and/or osteoporosis, depression. We also plan to determine the differential effects of intervention between urban and rural area.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National Health Research Institutes, Taiwan","enrollment":406,"countries":["Taiwan"],"start_date":"2008-04-01","completion_date":"2010-12-01","last_update_date":"2015-06-25","source_url":"https://clinicaltrials.gov/study/NCT00718432","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:22.160691+00:00","last_seen_at":"2026-09-25T06:20:19.667+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 79 Years","comparator":"UC group","organization":"National Health Research Institutes, Taiwan","interventions":["Exercise and nutritional integrated care","Usual care with education","Problem solving therapy (PST) integrated care"],"registry_source":"ClinicalTrials.gov","outcome_measures":["improvement of frailty — baseline, 3, 6, and 12 months","Bone Mineral Density — baseline and 12 months","quality of life assessment — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline, 6, and 12 months","QUALEFFO_31 — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline, 6, and 12 months","barthel index — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline and 12 months","PRIME-MD (only measured in pilot study) — baseline, 3, 6, and 12 months","BDI-II (only measured in 2009 study) — baseline, 6, and 12 months","health-resource utilization — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline, 6, and 12 months","Original Frailty Indicators — baseline, 3, 6, and 12 months","timed up and go — baseline, 3, 6, and 12 months","one leg stand time — baseline, 3, 6, and 12 months","dominant hand grip strength — baseline, 3, 6, and 12 months","dominant knee extension power — baseline, 3, 6, and 12 months","vitamin B12 in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","vitamin D in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","CRP in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","testosterone in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","IL-6 in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months"],"design_description":"RANDOMIZED · FACTORIAL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Frailty","Osteoporosis","Depression","Exercise and nutritional integrated care","Usual care with education","Problem solving therapy (PST) integrated care"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: osteoporosis.","quality_checked_at":"2026-09-25T06:20:27.00315+00:00","duplicate_cluster_key":"id:nct00718432","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2008-04-01 to 2010-12-01","comparator":"UC group","confidence":"structured-source","population":"ALL · 65 Years to 79 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:19.769Z","intervention":["Exercise and nutritional integrated care","Usual care with education","Problem solving therapy (PST) integrated care"],"participants":406,"study_design":"RANDOMIZED · FACTORIAL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["improvement of frailty — baseline, 3, 6, and 12 months","Bone Mineral Density — baseline and 12 months","quality of life assessment — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline, 6, and 12 months","QUALEFFO_31 — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline, 6, and 12 months","barthel index — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline and 12 months","PRIME-MD (only measured in pilot study) — baseline, 3, 6, and 12 months","BDI-II (only measured in 2009 study) — baseline, 6, and 12 months","health-resource utilization — pilot study: baseline, 3, 6, and 12 months, 2009 study: baseline, 6, and 12 months","Original Frailty Indicators — baseline, 3, 6, and 12 months","timed up and go — baseline, 3, 6, and 12 months","one leg stand time — baseline, 3, 6, and 12 months","dominant hand grip strength — baseline, 3, 6, and 12 months","dominant knee extension power — baseline, 3, 6, and 12 months","vitamin B12 in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","vitamin D in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","CRP in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","testosterone in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months","IL-6 in blood — pilot study: baseline and 12 month, 2009 study: baseline and 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"bone-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoporosis.","Abstract contains controlled term: osteoporosis.","Source terminology contains: osteoporosis.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Bone ageing","slug":"bone-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/40211","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}