{"type":"trials","record":{"id":40925,"source_id":"clinicaltrials-gov","external_id":"NCT02888119","title":"Imaging Biomarkers of Knee Osteoarthritis","brief_summary":"This study aims to develop, evaluate and translate highly accelerated imaging sequences (each protocol under 5 minutes) for in-vivo knee Osteoarthritis applications on a standard clinical 3T scanner using novel compression sensing and parallel imaging strategies.The overarching objective of the study is to establish a non-invasive imaging biomarker based on the development of rapid relaxation mapping with compressed sensing (CS) that will be clinically useful for assessment of early Osteoarthritis. A total of 90 subjects including 30 patients with high risk of developing knee osteoarthritis (OA), 30 patients with mild OA and 30 healthy controls will be accrued.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"NYU Langone Health","enrollment":50,"countries":["United States"],"start_date":"2016-07-01","completion_date":"2021-12-13","last_update_date":"2022-12-27","source_url":"https://clinicaltrials.gov/study/NCT02888119","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:26.536053+00:00","last_seen_at":"2026-09-25T06:15:20.281+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"40 Years to 75 Years","comparator":"High Risk for Osteoarthritis; Mild Osteoarthritis; Healthy Controls","organization":"NYU Langone Health","interventions":["PRISMA 3T MRI scanner (Siemens Medical Solutions)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change From Baseline in T1ρ Relaxation Time — Baseline, Month 24","Change From Baseline in T2 Relaxation Time — Baseline, Month 24","Change From Baseline in Western Ontario and McMaster University OA Index (WOMAC) Score — Baseline, Month 24","Change From Baseline in Knee Injury and OA Outcomes Score (KOOS) — Baseline, Month 24","Change From Baseline in Physical Activity Scale for the Elderly (PASE) Scores — Baseline, 24 Months"],"design_description":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","source_has_results":true},"controlled_terms":["Osteoarthritis","PRISMA 3T MRI scanner (Siemens Medical Solutions)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: osteoarthritis.","quality_checked_at":"2026-09-25T06:15:30.843286+00:00","duplicate_cluster_key":"id:nct02888119","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-07-01 to 2021-12-13","comparator":"High Risk for Osteoarthritis; Mild Osteoarthritis; Healthy Controls","confidence":"structured-source","population":"ALL · 40 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:20.369Z","intervention":["PRISMA 3T MRI scanner (Siemens Medical Solutions)"],"participants":50,"study_design":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change From Baseline in T1ρ Relaxation Time — Baseline, Month 24","Change From Baseline in T2 Relaxation Time — Baseline, Month 24","Change From Baseline in Western Ontario and McMaster University OA Index (WOMAC) Score — Baseline, Month 24","Change From Baseline in Knee Injury and OA Outcomes Score (KOOS) — Baseline, Month 24","Change From Baseline in Physical Activity Scale for the Elderly (PASE) Scores — Baseline, 24 Months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"joint-cartilage-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoarthritis.","Abstract contains controlled term: osteoarthritis.","Source terminology contains: osteoarthritis.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Joint and cartilage ageing","slug":"joint-cartilage-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/40925","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}